Chronic Meningococcemia Cutaneous Lesions Involve Meningococcal Perivascular Invasion Through the Remodeling of Endothelial Barriers.

Nicolas Dupin (1, 2) , Hervé Lécuyer (2, 3, 4) , Agnès Carlotti (1) , Claire Poyart (5, 2, 1) , Mathieu Coureuil (2, 4) , Johan Chanal (5, 2) , Alain Schmitt (5) , Marie-Cécile Vacher-Lavenu (1, 2) , Muhamed-Kheir Taha (6) , Xavier Nassif (2, 3, 4) , Philippe Morand (2, 1, 5)

1 Hôpital Cochin [AP-HP]
2 UPD5 - Université Paris Descartes - Paris 5
3 CHU Necker - Enfants Malades [AP-HP]
4 Inserm U1002 - Pathogénie des infections systémiques
5 IC UM3 (UMR 8104 / U1016) - Institut Cochin
6 Infections Bactériennes Invasives

Chronic meningococcemia is a form of sepsis with frequent polymorphous skin lesions. Both in vivo and in vitro data suggest that, in these lesions, meningococci gain access from the capillary lumen to the peripheral extravascular compartment, in the absence of vascular dislocation, through a paraendothelial route.

Keywords: sepsis; dislocations; drug administration routes; endothelium; neisseria meningitidis; blood capillaries; skin lesion; meningococcemia; chronic

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Nicolas Dupin, Hervé Lécuyer, Agnès Carlotti, Claire Poyart, Mathieu Coureuil, et al.. Chronic Meningococcemia Cutaneous Lesions Involve Meningococcal Perivascular Invasion Through the Remodeling of Endothelial Barriers.. Clinical Infectious Diseases, 2012, 54 (8), pp.1162-1165. ⟨10.1093/cid/cis120⟩. ⟨pasteur-02085535⟩