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Emergence of New Virulent Neisseria meningitidis Serogroup C Sequence Type 11 Isolates in France.

Abstract : In France, there have been variations in the incidence of invasive meningococcal infection due to serogroup C isolates. Infection peaks were observed in 1992 and 2003 that involved isolates of phenotypes C:2a:P1.5,2 and/or C:2a:P1.5, which belong to the sequence type 11 (ST-11) clonal complex. We report an emergence of isolates belonging to the ST-11 clonal complex since 2003. These isolates displayed a new phenotype, C:2a:P1.7,1, caused infections that occurred as clusters, and were associated with increased infection severity and high virulence in mice. These isolates may be responsible for a peak in the incidence of serogroup C meningococcal infection in France, for which there is no routine vaccination to date.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02085474
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Submitted on : Saturday, March 30, 2019 - 6:45:41 PM
Last modification on : Monday, January 13, 2020 - 5:08:15 PM

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Ala-Eddine Deghmane, Isabelle Parent Du Châtelet, Marek Szatanik, Eva Hong, Corinne Ruckly, et al.. Emergence of New Virulent Neisseria meningitidis Serogroup C Sequence Type 11 Isolates in France.. Journal of Infectious Diseases, Oxford University Press (OUP), 2010, 202 (2), pp.247-250. ⟨10.1086/653583⟩. ⟨pasteur-02085474⟩

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