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Molecular typing methods for outbreak detection and surveillance of invasive disease caused by Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae, a review.

Odile Harrison 1, * Angela Brueggemann 1 Dominique Caugant 2 Arie van der Ende 3 Matthias Frosch 4 Stephen Gray 5 Sigrid Heuberger 6 Paula Krizova 7 Per Olcén 8 Mary Slack 9 Muhamed-Kheir Taha 10 Martin Maiden 1
* Corresponding author
1 Department of Zoology [Oxford]
2 NIPH - Norwegian Institute of Public Health [Oslo]
3 Reference Laboratory for Bacterial Meningitis [Amsterdam]
4 Institut für Hygiene und Mikrobiologie [Würzburg]
5 MRU - Meningococcal Reference Unit
6 Institute for Medical Microbiology and Hygiene [Graz]
7 National Reference Laboratory for Meningococcal Infections [Prague]
8 Department of Laboratory Medicine, Section Clinical Microbiology, University hospital, 70185 Örebro
9 Respiratory and Systemic Infection Laboratory
10 National Meningitis Reference Laboratory
Abstract : Invasive disease caused by the encapsulated bacteria Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae remains an important cause of morbidity and mortality worldwide, despite the introduction of successful conjugate polysaccharide vaccines that target disease-associated strains. In addition, resistance, or more accurately reduced susceptibility, to therapeutic antibiotics is spreading in populations of these organisms. There is therefore a continuing requirement for the surveillance of vaccine and non-vaccine antigens and antibiotic susceptibilities among isolates from invasive disease, which is only partially met by conventional methods. This need can be met with molecular and especially nucleotide sequence-based typing methods, which are fully developed in the case of N. meningitidis and which could be more widely deployed in clinical laboratories for S. pneumoniae and H. influenzae.
Keywords : Population Surveillance Streptococcus pneumoniae Pneumococcal Infections Neisseria meningitidis Disease Outbreaks Haemophilus Infections Haemophilus influenzae Humans Meningococcal Infections Microbial Sensitivity Tests Molecular Epidemiology Molecular Typing
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Submitted on : Friday, March 29, 2019 - 2:35:07 PM
Last modification on : Wednesday, July 1, 2020 - 10:36:02 AM

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Odile Harrison, Angela Brueggemann, Dominique Caugant, Arie van der Ende, Matthias Frosch, et al.. Molecular typing methods for outbreak detection and surveillance of invasive disease caused by Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae, a review.. Microbiology, Microbiology Society, 2011, 157 (8), pp.2181-2195. ⟨10.1099/mic.0.050518-0⟩. ⟨pasteur-02084184⟩

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