Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma - Archive ouverte HAL Access content directly
Journal Articles Nature Genetics Year : 2016

Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

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Ronnie George
  • Function : Author
Khaled Abu-Amero
  • Function : Author
Roopam Duvesh
  • Function : Author
Li Jia Chen
  • Function : Author
Zheng Li
Monisha E Nongpiur
  • Function : Author
Shamira A Perera
  • Function : Author
Chunyan Qiao
  • Function : Author
Hon-Tym Wong
  • Function : Author
Hiroshi Sakai
  • Function : Author
Mônica Barbosa De Melo
  • Function : Author
Mei-Chin Lee
  • Function : Author
Anita S Chan
  • Function : Author
Yaakub Azhany
  • Function : Author
Thi Lam Huong Dao
  • Function : Author
Yoko Ikeda
  • Function : Author
Rodolfo A Perez-Grossmann
  • Function : Author
Tomasz Zarnowski
  • Function : Author
Alexander C Day
  • Function : Author
Jost B Jonas
  • Function : Author
Pancy O S Tam
  • Function : Author
Tuan Anh Tran
  • Function : Author
Humaira Ayub
  • Function : Author
Farah Akhtar
  • Function : Author
Shazia Micheal
  • Function : Author
Paul T K Chew
  • Function : Author
Leyla A Aljasim
  • Function : Author
Tanuj Dada
  • Function : Author
Tam Thi Luu
  • Function : Author
Mona S Awadalla
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Naris Kitnarong
  • Function : Author
Boonsong Wanichwecharungruang
  • Function : Author
Yee Yee Aung
  • Function : Author
Jelinar Mohamed-Noor
  • Function : Author
Saravanan Vijayan
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Sripriya Sarangapani
  • Function : Author
Rahat Husain
  • Function : Author
Aliza Jap
  • Function : Author
Mani Baskaran
  • Function : Author
David Goh
  • Function : Author
Daniel H Su
  • Function : Author
Huaizhou Wang
  • Function : Author
Vernon K Yong
  • Function : Author
Leonard W Yip
  • Function : Author
Tuyet Bach Trinh
  • Function : Author
Manchima Makornwattana
  • Function : Author
Thanh Thu Nguyen
  • Function : Author
Edgar U Leuenberger
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Ki-Ho Park
  • Function : Author
Widya Artini Wiyogo
  • Function : Author
Rajesh S Kumar
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Celso Tello
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Yasuo Kurimoto
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Suman S Thapa
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Kessara Pathanapitoon
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John F Salmon
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Yong Ho Sohn
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Antonio Fea
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Mineo Ozaki
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Jimmy S M Lai
  • Function : Author
Visanee Tantisevi
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Chaw Chaw Khaing
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Takanori Mizoguchi
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Satoko Nakano
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Chan-Yun Kim
  • Function : Author
Guangxian Tang
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Sujie Fan
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Renyi Wu
  • Function : Author
Hailin Meng
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Thi Thuy Giang Nguyen
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Tien Dat Tran
  • Function : Author
Morio Ueno
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Jose Maria Martinez
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Norlina Ramli
  • Function : Author
Yin Mon Aung
  • Function : Author
Rigo Daniel Reyes
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Stephen A Vernon
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Seng Kheong Fang
  • Function : Author
Zhicheng Xie
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Xiao Yin Chen
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Jia Nee Foo
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Kar Seng Sim
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Tina T Wong
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Desmond T Quek
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Rengaraj Venkatesh
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Srinivasan Kavitha
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Subbiah R Krishnadas
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Nagaswamy Soumittra
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Balekudaru Shantha
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Boon-Ang Lim
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Jeanne Ogle
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José P C De Vasconcellos
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Vital P Costa
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Ricardo y Abe
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Bruno B De Souza
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Chelvin C Sng
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Maria C Aquino
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Ewa Kosior-Jarecka
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Guillermo Barreto Fong
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Vania Castro Tamanaja
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Ricardo Fujita
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Yuzhen Jiang
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Naushin Waseem
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Sancy Low
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Huan Nguyen Pham
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Sami Al-Shahwan
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E Randy Craven
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Muhammad Imran Khan
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Rrima Dada
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Kuldeep Mohanty
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Muneeb A Faiq
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Alex W Hewitt
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Kathryn P Burdon
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Eng Hui Gan
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Anuwat Prutthipongsit
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Thipnapa Patthanathamrongkasem
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Mary Ann T Catacutan
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Irene R Felarca
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Chona S Liao
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Emma Rusmayani
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Vira Wardhana Istiantoro
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Giulia Consolandi
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Giulia Pignata
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Carlo Lavia
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Prin Rojanapongpun
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Lerprat Mangkornkanokpong
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Sunee Chansangpetch
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Jonathan C H Chan
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Bonnie N K Choy
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Jennifer W H Shum
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Hlaing May Than
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Khin Thida Oo
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Aye Thi Han
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Victor H Yong
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Xiao-Yu Ng
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Shuang Ru Goh
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Yaan Fun Chong
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Martin L Hibberd
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Mark Seielstad
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Eileen Png
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Sarah J Dunstan
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Nguyen van Vinh Chau
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Jinxin Bei
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Yi Xin Zeng
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Abhilasha Karkey
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Buddha Basnyat
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Francesca Pasutto
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Daniela Paoli
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Paolo Frezzotti
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Jie Jin Wang
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Paul Mitchell
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John H Fingert
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R Rand Allingham
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Michael A Hauser
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Soon Thye Lim
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Soo Hong Chew
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Richard P Ebstein
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Kyu Hyung Park
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Jeeyun Ahn
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Greet Boland
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Harm Snippe
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Richard Stead
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Raquel Quino
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Su Nyunt Zaw
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Urszula Lukasik
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Rohit Shetty
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Mimiwati Zahari
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Hyoung Won Bae
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Nay Lin Oo
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Toshiaki Kubota
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Anita Manassakorn
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Wing Lau Ho
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Laura Dallorto
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Young Hoon Hwang
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Christine A Kiire
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Masako Kuroda
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Zeiras Eka Djamal
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Jovell Ian M Peregrino
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Arkasubhra Ghosh
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Jin Wook Jeoung
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Tung S Hoan
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Nuttamon Srisamran
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Thayanithi Sandragasu
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Saw Htoo Set
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Vi Huyen Doan
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Shomi S Bhattacharya
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Ching-Lin Ho
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Donald T Tan
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Ramanjit Sihota
  • Function : Author
Seng-Chee Loon
  • Function : Author
Kazuhiko Mori
  • Function : Author
Shigeru Kinoshita
  • Function : Author
Anneke I Den Hollander
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Raheel Qamar
  • Function : Author
Ya-Xing Wang
  • Function : Author
Yik y Teo
  • Function : Author
E-Shyong Tai
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Curt Hartleben-Matkin
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David Lozano-Giral
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Seang Mei Saw
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Ching-Yu Cheng
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Juan C Zenteno
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Chi Pui Pang
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Huong T T Bui
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Owen Hee
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Jamie E Craig
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Deepak P Edward
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Michiko Yonahara
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Jamil Miguel Neto
  • Function : Author
Maria L Guevara-Fujita
  • Function : Author
Liang Xu
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Robert Ritch
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Ahmad Tajudin Liza-Sharmini
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Tien y Wong
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Saleh Al-Obeidan
  • Function : Author
Nhu Hon Do
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Periasamy Sundaresan
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Clement C Tham
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Paul J Foster
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Lingam Vijaya
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Abstract

Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10(-15)), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10(-16)), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10(-14)), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10(-11)), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10(-12)). We also confirmed significant association at three previously described loci (P < 5 × 10(-8) for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG.

Dates and versions

pasteur-02083054 , version 1 (28-03-2019)

Identifiers

Cite

Chiea Chuen Khor, Tan Do, Hongyan Jia, Masakazu Nakano, Ronnie George, et al.. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nature Genetics, 2016, 48 (5), pp.556-562. ⟨10.1038/ng.3540⟩. ⟨pasteur-02083054⟩

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