D. P. Kwiatkowski, How malaria has affected the human genome and what human genetics can teach us about malaria, Am J Hum Genet, vol.77, issue.2, p.16001361, 2005.

S. E. Bongfen, A. Laroque, J. Berghout, and P. Gros, Genetic and genomic analyses of host-pathogen interactions in malaria, Trends Parasitol, vol.25, issue.9, pp.417-439, 2009.

G. Min-oo and P. Gros, Erythrocyte variants and the nature of their malaria protective effect, Cell Microbiol, vol.7, issue.6, p.15888079, 2005.

T. N. Williams, S. Wambua, S. Uyoga, A. Macharia, J. K. Mwacharo et al., Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya, Blood, vol.106, issue.1, p.15769889, 2005.

P. Rihet, Y. Traore, L. Abel, C. Aucan, T. Traore-leroux et al., Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31-q33, Am J Hum Genet, vol.63, issue.2, p.9683598, 1998.
URL : https://hal.archives-ouvertes.fr/hal-01595931

W. Phimpraphi, R. Paul, B. Witoonpanich, C. Turbpaiboon, C. Peerapittayamongkol et al., Heritability of P. falciparum and P. vivax malaria in a Karen population in Thailand, PLoS One, vol.3, issue.12, p.3887, 2008.

Y. R. Lawaly, A. Sakuntabhai, L. Marrama, L. Konate, W. Phimpraphi et al., Heritability of the human infectious reservoir of malaria parasites, PLoS One, vol.5, issue.6, p.20613877, 2010.
URL : https://hal.archives-ouvertes.fr/pasteur-00557029

A. Sakuntabhai, R. Ndiaye, I. Casademont, C. Peerapittayamongkol, C. Rogier et al., Genetic determination and linkage mapping of Plasmodium falciparum malaria related traits in Senegal, PLoS One, vol.3, issue.4, p.2000, 2008.

C. Timmann, J. A. Evans, I. R. Konig, A. Kleensang, F. Ruschendorf et al., Genome-wide linkage analysis of malaria infection intensity and mild disease, PLoS Genet, vol.3, issue.3, p.17381244, 2007.

M. Jallow, Y. Y. Teo, K. S. Small, K. A. Rockett, P. Deloukas et al., Genome-wide and fine-resolution association analysis of malaria in West Africa, Nat Genet, vol.41, issue.6, pp.657-65, 2009.

C. Louicharoen, P. E. Paul, R. Nuchprayoon, I. Witoonpanich, B. Peerapittayamongkol et al., Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians, Science, vol.326, issue.5959, pp.1546-1555, 2009.

P. A. Zimmerman, I. Woolley, G. L. Masinde, S. M. Miller, D. T. Mcnamara et al., Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea, Proc Natl Acad Sci, vol.96, issue.24, p.10570183, 1999.

L. H. Miller, S. J. Mason, D. F. Clyde, and M. H. Mcginniss, The resistance factor to Plasmodium vivax in blacks. The Duffy-blood-group genotype, FyFy, N Engl J Med, vol.295, issue.6, p.778616, 1976.

A. G. Maier, M. T. Duraisingh, J. C. Reeder, S. S. Patel, J. W. Kazura et al., Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations, Nat Med, vol.9, issue.1, p.12469115, 2003.

B. Genton, F. Yaman, C. S. Mgone, N. Alexander, M. M. Paniu et al., PMID: 8524388 Modulation of Malaria Phenotypes by, Pyruvate Kinase PLOS ONE, vol.378, issue.6557, pp.564-569, 1995.

M. J. Friedman, Erythrocytic mechanism of sickle cell resistance to malaria, Proc Natl Acad Sci, vol.75, issue.4, p.347452, 1978.

K. Ayi, F. Turrini, A. Piga, and P. Arese, Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait, Blood, vol.104, issue.10, p.15280204, 2004.

D. Modiano, G. Luoni, B. S. Sirima, A. Lanfrancotti, V. Petrarca et al., The lower susceptibility to Plasmodium falciparum malaria of Fulani of Burkina Faso (west Africa) is associated with low frequencies of classic malaria-resistance genes, Trans R Soc Trop Med Hyg, vol.95, issue.2, p.11355545, 2001.

N. F. Olivieri, G. M. Muraca, O. Donnell, A. Premawardhena, A. Fisher et al., Studies in haemoglobin E beta-thalassaemia, Br J Haematol, vol.141, issue.3, pp.388-97, 2008.

F. P. Mockenhaupt, S. Ehrhardt, S. Gellert, R. N. Otchwemah, E. Dietz et al., Alpha(+)-thalassemia protects African children from severe malaria, Blood, vol.104, issue.7, p.15198952, 2004.

J. A. Rowe, D. H. Opi, and T. N. Williams, Blood groups and malaria: fresh insights into pathogenesis and identification of targets for intervention, Curr Opin Hematol, vol.16, issue.6, pp.480-487, 2009.

A. E. Fry, M. J. Griffiths, S. Auburn, M. Diakite, J. T. Forton et al., Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria, Hum Mol Genet, vol.17, issue.4, p.18003641, 2008.

R. Van-wijk and W. W. Van-solinge, The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis, Blood, vol.106, issue.13, p.16051738, 2005.

A. Zanella and P. Bianchi, Red cell pyruvate kinase deficiency: from genetics to clinical manifestations, Baillieres Best Pract Res Clin Haematol, vol.13, issue.1, p.10916678, 2000.

H. Kanno, H. Fujii, and S. Miwa, Structural analysis of human pyruvate kinase L-gene and identification of the promoter activity in erythroid cells, Biochem Biophys Res Commun, vol.188, issue.2, p.1445295, 1992.

R. Van-wijk, E. G. Huizinga, A. C. Van-wesel, B. A. Van-oirschot, M. A. Hadders et al., Fifteen novel mutations in PKLR associated with pyruvate kinase (PK) deficiency: structural implications of amino acid substitutions in PK, Hum Mutat, vol.30, issue.3, pp.446-53, 2009.

R. K. Gupta and R. M. Oesterling, Dual divalent cation requirement for activation of pyruvate kinase; essential roles of both enzyme-and nucleotide-bound metal ions, Biochemistry, vol.15, issue.13, p.7293, 1976.

W. N. Valentine, K. R. Tanaka, and S. Miwa, A specific erythrocyte glycolytic enzyme defect (pyruvate kinase) in three subjects with congenital non-spherocytic hemolytic anemia, Trans Assoc Am Physicians, vol.74, p.13924348, 1961.

A. Hirono, H. Kanno, S. Miwa, and E. Beutler, Pyruvate kinase deficiency and other enzymopathies of the erythrocyte, pp.4637-64, 2001.

K. Ayi, G. Min-oo, L. Serghides, M. Crockett, M. Kirby-allen et al., Pyruvate kinase deficiency and malaria, N Engl J Med, vol.358, issue.17, pp.1805-1815, 2008.

G. Min-oo, A. Fortin, M. F. Tam, P. Gros, and M. M. Stevenson, Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model, Genes Immun, vol.5, issue.3, p.15029238, 2004.

G. Min-oo, A. Fortin, M. F. Tam, A. Nantel, M. M. Stevenson et al., Pyruvate kinase deficiency in mice protects against malaria, Nat Genet, vol.35, issue.4, p.14595440, 2003.

P. M. Durand and T. L. Coetzer, Pyruvate kinase deficiency protects against malaria in humans. Haematologica, vol.93, 2008.

J. Berghout, S. Higgins, C. Loucoubar, A. Sakuntabhai, K. C. Kain et al., Genetic diversity in human erythrocyte pyruvate kinase, Genes Immun, vol.13, issue.1, pp.98-102, 2012.
DOI : 10.1038/gene.2011.54
URL : https://hal.archives-ouvertes.fr/pasteur-02069000

P. Machado, L. Manco, C. Gomes, C. Mendes, N. Fernandes et al., Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria, PLoS One, vol.7, issue.10, p.47071, 2012.

J. Alves, P. Machado, J. Silva, N. Goncalves, L. Ribeiro et al., Analysis of malaria associated genetic traits in Cabo Verde, a melting pot of European and sub Saharan settlers, Blood Cells Mol Dis, vol.44, issue.1, pp.62-70, 2010.

W. Phimpraphi, R. E. Paul, S. Yimsamran, S. Puangsa-art, N. Thanyavanich et al., Longitudinal study of Plasmodium falciparum and Plasmodium vivax in a Karen population in Thailand

, Malar J, vol.7, p.99, 2008.

J. F. Trape, C. Rogier, L. Konate, N. Diagne, H. Bouganali et al., The Dielmo project: a longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of Senegal, Am J Trop Med Hyg, vol.51, issue.2, p.8074247, 1994.

C. Rogier, D. Commenges, and J. F. Trape, Evidence for an age-dependent pyrogenic threshold of Plasmodium falciparum parasitemia in highly endemic populations, Am J Trop Med Hyg, vol.54, issue.6, p.8686780, 1996.

C. Rogier, A. B. Ly, A. Tall, B. Cisse, and J. F. Trape, Plasmodium falciparum clinical malaria in Dielmo, a holoendemic area in Senegal: no influence of acquired immunity on initial symptomatology and severity of malaria attacks, Am J Trop Med Hyg, vol.60, issue.3, 1999.

C. Rogier, A. Tall, N. Diagne, D. Fontenille, A. Spiegel et al., Plasmodium falciparum clinical malaria: lessons from longitudinal studies in Senegal, Parassitologia, vol.41, issue.1-3, p.10697865, 1999.

T. A. Hall, BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT, Nucleic Acids Symposium Series, vol.41, pp.95-103, 1999.

J. C. Barrett, B. Fry, J. Maller, and M. J. Daly, Haploview: analysis and visualization of LD and haplotype maps, Bioinformatics, vol.21, issue.2, p.15297300, 2005.
DOI : 10.1093/bioinformatics/bth457
URL : https://academic.oup.com/bioinformatics/article-pdf/21/2/263/456887/bth457.pdf

J. R. O'connell and D. E. Weeks, PedCheck: a program for identification of genotype incompatibilities in linkage analysis, Am J Hum Genet, vol.63, issue.1, p.9634505, 1998.

A. Fortin, L. R. Cardon, M. Tam, E. Skamene, M. M. Stevenson et al., Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice, Proc Natl Acad Sci U S A, vol.98, p.11535821, 2001.

G. Valentini, L. R. Chiarelli, R. Fortin, M. Dolzan, A. Galizzi et al., Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia, J Biol Chem, vol.277, issue.26, p.11960989, 2002.
DOI : 10.1074/jbc.m202107200
URL : http://www.jbc.org/content/277/26/23807.full.pdf

D. Modiano, V. Petrarca, B. S. Sirima, A. Bosman, I. Nebie et al., Plasmodium falciparum malaria in sympatric ethnic groups of Burkina Faso, west Africa, Parassitologia, vol.37, issue.2-3, p.8778668, 1995.

A. B. Tiono, S. B. Sirima, and K. Hamed, Fulani show decreased susceptibility to Plasmodium falciparum infection versus Mossi: data from a community-wide screening and treatment of asymptomatic carriers in Burkina Faso, Malar J, vol.12, p.23680454, 2013.

M. Summerer, J. Horst, G. Erhart, H. Weissensteiner, S. Schonherr et al., Large-scale mitochondrial DNA analysis in Southeast Asia reveals evolutionary effects of cultural isolation in the multiethnic population of Myanmar, BMC Evol Biol, vol.14, p.17, 2014.

M. Morimoto, H. Kanno, H. Asai, T. Tsujimura, H. Fujii et al., Pyruvate kinase deficiency of mice associated with nonspherocytic hemolytic anemia and cure of the anemia by marrow transplantation without host irradiation, Blood, vol.86, issue.11, 1995.

, WHO Organization. WHO Global Malaria Programme: World Malaria Report, p.7, 2013.

, WHO Organization. Malaria: Fact sheet No94, 2015.

P. W. Hedrick, Population genetics of malaria resistance in humans, Heredity (Edinb), vol.107, issue.4, pp.283-304, 2011.

P. W. Hedrick, Resistance to malaria in humans: the impact of strong, recent selection, Malar J, vol.11, p.349, 2012.

T. Smith, B. Genton, K. Baea, N. Gibson, A. Narara et al., Prospective risk of morbidity in relation to malaria infection in an area of high endemicity of multiple species of Plasmodium, Am J Trop Med Hyg, vol.64, issue.5-6, p.11463113, 2001.

A. Zanella, E. Fermo, P. Bianchi, and G. Valentini, Red cell pyruvate kinase deficiency: molecular and clinical aspects, Br J Haematol, vol.130, issue.1, p.15982340, 2005.

C. Wang, L. R. Chiarelli, P. Bianchi, D. J. Abraham, A. Galizzi et al., Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia, Blood, vol.98, issue.10, p.11698298, 2001.

A. Kahn and J. Marie, Pyruvate kinases from human erythrocytes and liver, Methods Enzymol, vol.90, p.7154942, 1982.

J. Marie, H. Buc, M. P. Simon, and A. Kahn, Phosphorylation of human erythrocyte pyruvate kinase by soluble cyclic-AMP-dependent protein kinases. Comparison with human liver L-type enzyme, Eur J Biochem, vol.108, issue.1, p.6250830, 1980.

E. Fermo, P. Bianchi, L. R. Chiarelli, F. Cotton, C. Vercellati et al., Red cell pyruvate kinase deficiency: 17 new mutations of the PK-LR gene, Br J Haematol, vol.129, issue.6, p.15953013, 2005.

C. Zurcher, J. A. Loos, and H. K. Prins, Hereditary high ATP content of human erythrocytes, Folia Haematol Int Mag Klin Morphol Blutforsch, vol.83, issue.4, p.4160306, 1965.

E. Beutler, B. Westwood, R. Van-zwieten, and D. Roos, G->T transition at cDNA nt 110 (K37Q) in the PKLR (pyruvate kinase) gene is the molecular basis of a case of hereditary increase of red blood cell ATP, Hum Mutat, vol.9, issue.3, p.9090535, 1997.

J. Marie and A. Kahn, Proteolytic processing of human erythrocyte pyruvate kinase: study of normal and deficient enzymes, Biochem Biophys Res Commun, vol.91, issue.1, p.518614, 1979.

A. N. Fanjul and R. N. Farias, Cold-sensitive cytosolic 3,5,3'-triiodo-L-thyronine-binding protein and pyruvate kinase from human erythrocytes share similar regulatory properties of hormone binding by glycolytic intermediates, J Biol Chem, vol.268, issue.1, p.8416925, 1993.

V. Gupta and R. N. Bamezai, Human pyruvate kinase M2: a multifunctional protein, Protein Sci, vol.19, issue.11, pp.2031-2075, 2010.

J. J. Strandholm, R. D. Dyson, and J. M. Cardenas, Bovine pyruvate kinase isozymes and hybrid isozymes, Arch Biochem Biophys, vol.173, issue.1, p.1259434, 1976.

J. M. Cardenas and R. D. Dyson, Mammalian pyruvate kinase hybrid isozymes: tissue distribution and physiological significance, J Exp Zool, vol.204, issue.3, p.660140, 1978.

J. M. Cardenas, T. C. Richards, and L. Gabourel, Localization of pyruvate kinase isozymes in bovine kidney and comparison of these patterns with those of lactate dehydrogenases and aldolases, J Cell Physiol, vol.96, issue.2, p.670304, 1978.

P. A. Mueggler, S. Carpenter, and J. A. Black, Postnatal changes in canine erythrocyte pyruvate kinase isozymes, Biochem Genet, vol.21, issue.7-8, p.6626141, 1983.