Principles of chromosomal organization: lessons from yeast

Christophe Zimmer (1) , Emmanuelle Fabre (2, 3)

1 Imagerie et Modélisation
2 Génétique Moléculaire des Levures
3 Régulation spatiale des fonctions génomiques

The spatial organization of genes and chromosomes plays an important role in the regulation of several DNA processes. However, the principles and forces underlying this nonrandom organization are mostly unknown. Despite its small dimension, and thanks to new imaging and biochemical techniques, studies of the budding yeast nucleus have led to significant insights into chromosome arrangement and dynamics. The dynamic organization of the yeast genome during interphase argues for both the physical properties of the chromatin fiber and specific molecular interactions as drivers of nuclear order.

Domains: Life Sciences [q-bio]; Santé publique et épidémiologie

Christophe Zimmer, Emmanuelle Fabre. Principles of chromosomal organization: lessons from yeast. Journal of Cell Biology, 2011, 192 (5), pp.723-733. ⟨10.1083/jcb.201010058⟩. ⟨pasteur-02079552⟩