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Journal articles
MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment
Abstract : Graphical Abstract Highlights d Ubiquitin signaling factors interact with NS2 and play a role in HCV infection d MARCH8 mediates K63-linked ubiquitination of HCV NS2 and ESCRT recruitment d MARCH8 is required for Flaviviridae infection and intracellular envelopment of HCV d MARCH8 is a potential target for host-targeted antiviral strategies In Brief The mechanisms that regulate intracellular viral envelopment are unknown. Kumar et al. report that MARCH8 catalyzes K63-linked polyubiquitination of the HCV nonstructural 2 protein and subsequently ESCRT recruitment and HCV envelopment. MARCH8 is required for infection with other Flaviviridae family members, thereby representing a potential host target for antiviral strategies.
Cited literature [70 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02077482
Contributor : Caroline Demeret Connect in order to contact the contributor
Submitted on : Friday, March 22, 2019 - 6:46:59 PM
Last modification on : Tuesday, October 19, 2021 - 10:28:14 PM
Long-term archiving on: : Sunday, June 23, 2019 - 4:26:10 PM
Contributor : Caroline Demeret Connect in order to contact the contributor
Submitted on : Friday, March 22, 2019 - 6:46:59 PM
Last modification on : Tuesday, October 19, 2021 - 10:28:14 PM
Long-term archiving on: : Sunday, June 23, 2019 - 4:26:10 PM
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