Skip to Main content Skip to Navigation
Journal articles

Efficacy of an oral live vaccine for veterinary use against pseudotuberculosis

Abstract : Pseudotuberculosis, an infection caused by the ubiquitous enteropathogenic bacterium Yersinia pseudotuberculosis, is a recurrent veterinary problem in livestock and zoo animals. The only vaccine currently available in zoos is Pseudovac (a mixture of killed strains of various serotypes), but its efficacy is not well established. We show here that Pseudovac does not protect guinea pigs against a severe Y. pseudotuberculosis infection. We thus evaluated the possibility of using a live attenuated Y. pseudotuberculosis strain (IP32680) as an oral vaccine against animal pseudotuberculosis. We report that IP32680 is avirulent for guinea pigs and induces a strong IgG response against various serotypes of Y. pseudotuberculosis. One and two oral inoculations of IP32680 provided 50% and 83% protection, respectively against a severe infection with a highly pathogenic strain. The avirulent Y. pseudotuberculosis IP32680 is therefore much more protective than Pseudovac and may represent a valuable oral vaccine against pseudotuberculosis in zoo animals.
Complete list of metadatas

Cited literature [35 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02075702
Contributor : Christian E. Demeure <>
Submitted on : Thursday, March 21, 2019 - 3:17:29 PM
Last modification on : Monday, January 13, 2020 - 5:08:05 PM
Long-term archiving on: : Saturday, June 22, 2019 - 3:06:42 PM

File

Quintard preprint 2010.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Benoît Quintard, Thierry Petit, Nathalie Ruvoen, Elisabeth Carniel, Christian Demeure. Efficacy of an oral live vaccine for veterinary use against pseudotuberculosis. Comparative Immunology, Microbiology and Infectious Diseases, Elsevier, 2010, 33 (6), pp.e59-e65. ⟨10.1016/j.cimid.2009.12.001⟩. ⟨pasteur-02075702⟩

Share

Metrics

Record views

110

Files downloads

330