Differential transcriptional control as the major molecular event in generating Otx1-/-and Otx2-/-divergent phenotypes, Development, vol.126, pp.1417-1426, 1999. ,
Targeted integration of DNA using mutant lox sites in embryonic stem cells, Nucleic Acids Res, vol.25, pp.868-872, 1997. ,
Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a desoxyribonucleic acid fraction isolated from Pneumococcus type III, J Exp Med, vol.79, pp.137-158, 1944. ,
, Mutant mice and neuroscience: recommendations concerning genetic background, Neuron, vol.19, pp.755-759, 1997.
Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes, Proc Natl Acad Sci U S A, vol.96, pp.1013-1018, 1999. ,
Ethylnitrosourea mutagenesis and the isolation of mutant alleles for specific genes located in the T region of mouse chromosome 17, Genetics, vol.108, pp.457-470, 1984. ,
Combining mutagenesis and genomics in the mouse -closing the phenotype gap, Trends Genet, vol.12, pp.433-435, 1996. ,
Embryonic stem cell-derived glial precursors: a source of myelinating transplants, Science, vol.285, pp.754-756, 1999. ,
Altering the genome by homologous recombination, Science, vol.244, pp.1288-1292, 1989. ,
Beyond 'knock-out' mice: new perspectives for the programmed modification of the mammalian genome, Mol Hum Reprod, vol.4, pp.929-938, 1998. ,
I-SceI -induced gene replacement at a natural locus in embryonic stem cells, Mol Cell Biol, vol.18, pp.1444-1448, 1998. ,
Mice lacking vimentin develop and reproduce without an obvious phenotype, Cell, vol.79, pp.679-694, 1994. ,
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells, Nature, vol.330, pp.576-578, 1987. ,
Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells, Mol Cell Biol, vol.18, pp.4070-4078, 1998. ,
Establishment in culture of pluripotential cells from mouse embryos, Nature, vol.292, pp.154-156, 1981. ,
Ligand-activated sitespecific recombination in mice, Proc Natl Acad Sci, vol.93, pp.10887-10890, 1996. ,
Analysis of mammalian cis-regulatory DNA elements by homologous recombination, Methods Enzymol, vol.306, pp.42-66, 1999. ,
Reflections on the biology of embryonic stem (ES) cells, Int J Dev Biol, vol.41, pp.235-243, 1997. ,
Rescue of cyclin D1 deficiency by knockin cyclin E, Cell, vol.97, pp.767-777, 1999. ,
Transgenesis by means of blastocyst-derived embryonic stem cell lines, Proc Natl Acad Sci, vol.83, pp.9065-9069, 1986. ,
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting, Science, vol.265, pp.103-106, 1994. ,
Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2, Science, vol.269, pp.679-682, 1995. ,
Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development, Development, vol.125, pp.4521-4530, 1998. ,
Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene, EMBO J, vol.18, pp.5931-5942, 1999. ,
Engineering chromosomes in mice through targeted meiotic recombination (TAMERE), Nat Genet, vol.20, pp.381-384, 1998. ,
Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed, Genes Dev, vol.9, pp.1667-1677, 1995. ,
Using targeted large deletions and high-efficiency N-ethyl-N-nitrosourea mutagenesis for functional analyses of the mammalian genome, Methods, vol.13, pp.423-436, 1997. ,
Regulation of Cre recombinase activity by the synthetic steroid RU 486, Nucleic Acids Res, vol.24, pp.1404-1411, 1996. ,
In vitro differentiation of embryonic stem cells, Curr Opin Cell Biol, vol.7, pp.862-869, 1995. ,
Identification of the cystic fibrosis gene: genetic analysis, Science, vol.245, pp.1073-1080, 1989. ,
Sitespecific recombinases: tools for genome engineering, Trends Genet, vol.9, pp.413-421, 1993. ,
Tissuespecific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes, Cell, vol.96, pp.329-339, 1999. ,
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells, Proc Natl Acad Sci U S A, vol.78, pp.7634-7638, 1981. ,
Production of gene-targeted sheep by nuclear transfer from cultured somatic cells, Nature, vol.405, pp.1066-1069, 2000. ,
An Fgf-8 mutant allelic series generated by Cre-and Flp-mediated recombination, Nature Genetics, vol.18, pp.136-141, 1998. ,
Mice with gene targetted prion protein alterations whow that Prnp, Sinc and Prni are congruent, Nat Genet An. Acad. Bras. Cienc, vol.73, issue.3, pp.118-124, 1998. ,
Human embryonic stem cells, J Cell Sci, vol.113, pp.5-10, 2000. ,
Chromosome engineering in mice, Nature, vol.378, pp.720-724, 1995. ,
Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro, Nat Biotechnol, vol.18, pp.399-404, 2000. ,
B lymphocyte-specific, Cre-mediated mutagenesis in mice, Nucleic Acids Res, vol.25, pp.1317-1318, 1997. ,
Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector, Nature, vol.323, pp.445-448, 1986. ,
Chimeras and mosaics in mouse mutant analysis, Trends Genet, vol.14, pp.358-363, 1998. ,
The MyoD family of transcription factors and skeletal myogenesis, Bioessays, vol.17, pp.203-209, 1995. ,
Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacement, Mech Dev, vol.75, pp.53-66, 1998. ,
Inducible gene targeting in mice using the Cre/lox system, Methods, vol.14, pp.381-392, 1998. ,
Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1, Proc Natl Acad Sci, vol.85, pp.5166-5170, 1988. ,
Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain, Cell, vol.75, pp.1199-1214, 1993. ,
Derivation of pluripotent stem cells from cultured human primordial germ cells, Proc Natl Acad Sci, vol.95, pp.13726-13731, 1998. ,
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene, Science, vol.278, pp.120-123, 1997. ,
Animal models of human genetic diseases, Trends Genet, vol.9, pp.112-116, 1993. ,
Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination, Nature, vol.317, pp.230-234, 1985. ,
Mammalian cloning, Nat Rev Genet, vol.1, pp.199-207, 2000. ,
Functional equivalency between Otx2 and Otx1 in development of the rostral head, Development, vol.126, pp.743-757, 1999. ,
Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice, Nature, vol.384, pp.266-70, 1996. ,
DOI : 10.1038/384266a0
, The Transgenic/Targeted Mutation Database, 2001.
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells, Cell, vol.51, pp.503-512, 1987. ,
Embryonic stem cell lines derived from human blastocysts, Science, vol.282, pp.1145-1147, 1998. ,
DOI : 10.1126/science.282.5391.1145
The essential role of hippocampal CA1 NMDA receptordependent synaptic plasticity in spatial memory, Cell, vol.87, pp.1327-1338, 1996. ,
Temporal, spatial, and cell type-specific control of Cremediated DNA recombination in transgenic mice, Nat Biotechnol, vol.17, pp.1091-1096, 1999. ,
,
, 73 (3) 1998. Cre expression in primary spermatocytes: a tool for genetic engineering of the germ line, An. Acad. Bras. Cienc, vol.51, pp.274-280, 2001.
Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently, Development, vol.124, pp.2507-2513, 1997. ,
Analysis of homologous recombination in cultured mammalian cells in transient expression and stable transformation assays, Somat Cell Mol Genet, vol.12, pp.63-72, 1986. ,
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation, Nat Genet, vol.22, pp.37-43, 1999. ,
Chromosomal deletion complexes in mice by radiation of embryonic stem cells, Nat Genet, vol.15, pp.285-288, 1997. ,
Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells, Nature, vol.392, pp.608-611, 1998. ,