EVER2 protein binds TRADD to promote TNF-α-induced apoptosis - Archive ouverte HAL Access content directly
Journal Articles Cell Death and Disease Year : 2013

EVER2 protein binds TRADD to promote TNF-α-induced apoptosis

(1) , (1) , (1) , (1) , (1)
1

Abstract

EVER1 and 2 confer resistance to cutaneous oncogenic human papillomavirus infections by downregulating the activating protein 1 (AP-1) signaling pathway. Defects in their expression are associated with susceptibility to epidermodysplasia verruciformis, which is characterized by persistent β-HPV infection, tumor necrosis factor alpha (TNF-α) overproduction in keratinocytes and the development of skin cancers. TNF-α-induced apoptosis is a key defense strategy, preventing the persistence of the virus within cells, but the role of EVER proteins in this cell death mechanism triggered by extrinsic stimuli is unknown. We show here that EVER2 induces TNF-α- and TRAIL-dependant apoptosis. It interacts with the N-terminal domain of TRADD, impairs the recruitment of TRAF2 and RIPK1 and promotes apoptosis. The skin cancer-associated EVER2 I306 allele results in an impaired TRADD-EVER2 interaction, with lower levels of cell death following treatment with TNF-α. These data highlight a new, critical function of EVER2 in controlling cell survival in response to death stimuli.
Fichier principal
Vignette du fichier
PMID 23429285.pdf (2.76 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

pasteur-02074046 , version 1 (27-03-2019)

Licence

Attribution - NonCommercial - NoDerivatives - CC BY 4.0

Identifiers

Cite

G Gaud, D. Guillemot, Y. Jacob, M. Favre, F. Vuillier. EVER2 protein binds TRADD to promote TNF-α-induced apoptosis. Cell Death and Disease, 2013, 4 (2), pp.e499. ⟨10.1038/cddis.2013.27⟩. ⟨pasteur-02074046⟩

Collections

PASTEUR
15 View
57 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More