Skip to Main content Skip to Navigation
Journal articles

EVER2 protein binds TRADD to promote TNF-α-induced apoptosis

Abstract : EVER1 and 2 confer resistance to cutaneous oncogenic human papillomavirus infections by downregulating the activating protein 1 (AP-1) signaling pathway. Defects in their expression are associated with susceptibility to epidermodysplasia verruciformis, which is characterized by persistent β-HPV infection, tumor necrosis factor alpha (TNF-α) overproduction in keratinocytes and the development of skin cancers. TNF-α-induced apoptosis is a key defense strategy, preventing the persistence of the virus within cells, but the role of EVER proteins in this cell death mechanism triggered by extrinsic stimuli is unknown. We show here that EVER2 induces TNF-α- and TRAIL-dependant apoptosis. It interacts with the N-terminal domain of TRADD, impairs the recruitment of TRAF2 and RIPK1 and promotes apoptosis. The skin cancer-associated EVER2 I306 allele results in an impaired TRADD-EVER2 interaction, with lower levels of cell death following treatment with TNF-α. These data highlight a new, critical function of EVER2 in controlling cell survival in response to death stimuli.
Document type :
Journal articles
Complete list of metadatas

Cited literature [37 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02074046
Contributor : Marie-Luce Kop <>
Submitted on : Wednesday, March 27, 2019 - 2:31:17 PM
Last modification on : Monday, March 9, 2020 - 11:18:05 AM
Long-term archiving on: : Friday, June 28, 2019 - 12:35:38 PM

File

PMID 23429285.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Collections

Citation

G Gaud, D. Guillemot, Y. Jacob, M. Favre, F. Vuillier. EVER2 protein binds TRADD to promote TNF-α-induced apoptosis. Cell Death and Disease, Nature Publishing Group, 2013, 4 (2), pp.e499. ⟨10.1038/cddis.2013.27⟩. ⟨pasteur-02074046⟩

Share

Metrics

Record views

58

Files downloads

163