Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage. - Institut Pasteur Access content directly
Journal Articles Vaccine Year : 2013

Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage.

Abstract

The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there were 17 Neisseria meningitidis carriers (carriage rate of 1.57%). MenBvac vaccination appeared associated with lower carriage rate, i.e., 0.31% among the vaccinated children versus 2.10% among the non-vaccinated (p=0.03). The beneficial effect on carriage was observed regardless of the strain serogroup. OMV-vaccinated mice also showed reduction of bacterial acquisition of OMV-homolog and hererolog strains in respiratory pathways after intranasal challenge. These results suggest that meningococcal OMV-based vaccines reduce meningococcal carriage and may hence confer herd immunity.

Domains

Vaccinology
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Dates and versions

pasteur-02073842 , version 1 (20-03-2019)

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Valérie Delbos, Ludovic Lemée, Jacques Benichou, Gilles Berthelot, Ala-Eddine Deghmane, et al.. Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage.. Vaccine, 2013, 31 (40), pp.4416-4420. ⟨10.1016/j.vaccine.2013.06.080⟩. ⟨pasteur-02073842⟩
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