HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage.

Abstract : The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there were 17 Neisseria meningitidis carriers (carriage rate of 1.57%). MenBvac vaccination appeared associated with lower carriage rate, i.e., 0.31% among the vaccinated children versus 2.10% among the non-vaccinated (p=0.03). The beneficial effect on carriage was observed regardless of the strain serogroup. OMV-vaccinated mice also showed reduction of bacterial acquisition of OMV-homolog and hererolog strains in respiratory pathways after intranasal challenge. These results suggest that meningococcal OMV-based vaccines reduce meningococcal carriage and may hence confer herd immunity.
Document type :
Journal articles
Complete list of metadata

Contributor : Marie Martin Connect in order to contact the contributor
Submitted on : Wednesday, March 20, 2019 - 11:46:18 AM
Last modification on : Thursday, April 7, 2022 - 10:10:35 AM



Valérie Delbos, Ludovic Lemée, Jacques Benichou, Gilles Berthelot, Ala-Eddine Deghmane, et al.. Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage.. Vaccine, Elsevier, 2013, 31 (40), pp.4416-4420. ⟨10.1016/j.vaccine.2013.06.080⟩. ⟨pasteur-02073842⟩



Record views