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Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage.

Abstract : The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there were 17 Neisseria meningitidis carriers (carriage rate of 1.57%). MenBvac vaccination appeared associated with lower carriage rate, i.e., 0.31% among the vaccinated children versus 2.10% among the non-vaccinated (p=0.03). The beneficial effect on carriage was observed regardless of the strain serogroup. OMV-vaccinated mice also showed reduction of bacterial acquisition of OMV-homolog and hererolog strains in respiratory pathways after intranasal challenge. These results suggest that meningococcal OMV-based vaccines reduce meningococcal carriage and may hence confer herd immunity.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02073842
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Submitted on : Wednesday, March 20, 2019 - 11:46:18 AM
Last modification on : Monday, January 13, 2020 - 5:08:17 PM

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Valérie Delbos, Ludovic Lemée, Jacques Benichou, Gilles Berthelot, Ala-Eddine Deghmane, et al.. Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage.. Vaccine, Elsevier, 2013, 31 (40), pp.4416-4420. ⟨10.1016/j.vaccine.2013.06.080⟩. ⟨pasteur-02073842⟩

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