Gram-scale synthesis of luciferins derived from coelenterazine and original insights into their bioluminescence properties

Eloi Coutant; Sophie Goyard; Vincent Hervin; Glwadys Gagnot; Racha Baatallah; Yves Jacob; Thierry Rose; Yves Janin

doi:10.1039/c9ob00459a

Journal articles

Gram-scale synthesis of luciferins derived from coelenterazine and original insights into their bioluminescence properties

Eloi Coutant ¹ Sophie Goyard ² Vincent Hervin ¹ Glwadys Gagnot ^{1, 3} Racha Baatallah ¹ Yves Jacob ⁴ Thierry Rose ^{2, *} Yves Janin ^{1, *}

* Corresponding author

1 Chimie et Biocatalyse

2 CITECH - Centre de Recherche et Innovation Technologique

3 UPD5 - Université Paris Descartes - Paris 5

4 GMV-ARN (UMR_3569 / U-Pasteur_2) - Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses

Abstract : An original gram-scale synthesis of O-acetylated forms of coelenterazine, furimazine or hydroxy-bearing analogues of luciferins is described. The comparison over two hours of their bioluminescence, using the nanoKAZ/NanoLuc luciferase, provides remarkable insights useful for the selection of a substrate adapted for a given application.

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Journal articles

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Chemical Sciences / Organic chemistry

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Submitted on : Wednesday, October 23, 2019 - 11:21:53 AM
Last modification on : Monday, January 11, 2021 - 2:30:05 PM
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Gram-scale synthesis of luciferins derived from coelenterazine and original insights into their bioluminescence properties

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Gram-scale synthesis of luciferins derived from coelenterazine and original insights into their bioluminescence properties

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