Linkage disequilibrium of polymorphic RAET1 genes in Thais

S. Rareongjai (1, 2) , A. Romphruk (1) , A. V. Romphruk (1) , Anavaj Sakuntabhai (3) , C. Leelayuwat (1)

1 KKU - Khon Kaen University [Thailand]
2 University of Phayao
3 Génétique de la Réponse aux Infections chez l'Homme

Retinoic acid early transcripts-1 (RAET1) or unique long 16 (UL-16) binding proteins (ULBPs) is a gene cluster encoding for molecules acting as ligands to natural killer group 2 D (NKG2D), a receptor expressed on immune cells. Binding of these ligands to the receptor activates immune cells leading to killing of tumor cells and also viral-infected cells. The information on polymorphism of RAET1 is limited. In this report, we analyze the linkages between four polymorphic RAET1 genes: RAET1E, RAET1G, RAET1H and RAET1L, in 318 unrelated Thais. The strongest linkage disequilibrium was found between RAET1E and RAET1G, with P-value, D' and r(2) of <5.0 x 10(-5), 0.707 and 0.840, respectively. RAET1E(*)001 was found to be in linkage disequilibrium with RAET1G(*)002, and RAET1E(*)002 with RAET1G(*)001. Evidently, there were possible RAET1 haplotypes with haplotype frequencies of more than 10% consisting of RAET1E(*)001; RAET1G(*)002; RAET1H(*)001; RAET1L(*)001 and RAET1E(*)002; RAET1G(*)001; RAET1H(*)002; RAET1L(*)003. This study provides basic information on polymorphisms of RAET1 and possible RAET1 haplotypes in Thais.

Domaines: Génétique

S. Rareongjai, A. Romphruk, A. V. Romphruk, Anavaj Sakuntabhai, C. Leelayuwat. Linkage disequilibrium of polymorphic RAET1 genes in Thais. Tissue Antigens, 2010, 76 (3), pp.230-235. ⟨10.1111/j.1399-0039.2010.01502.x⟩. ⟨pasteur-02068981⟩