Skip to Main content Skip to Navigation
Journal articles

Epidemiological impact and cost-effectiveness of introducing vaccination against serogroup B meningococcal disease in France.

Abstract : INTRODUCTION: Despite its low incidence in France, invasive serogroup B meningococcal disease remains a public health concern. A new vaccine against the disease, Bexsero(®), has been licensed in the EU. We studied the epidemiological impact and cost-effectiveness of routine vaccination using Bexsero(®) in order to inform the decision-making process regarding its potential inclusion in the vaccination schedule. METHODS: A multi-generational Markov model was used. Time horizon was set to 100 years. Five vaccination strategies were evaluated: infants at 3, 5, 6 and 13 months, toddlers at 13, 15 and 27 months and adolescents at 15 years provided 2 doses one month apart. A booster dose at 15 years old and a catch-up for 15 years old subjects during the first 15 years of the programme were added to the infant and toddler strategies. Costs per QALY gained were computed from a restricted societal perspective including direct costs only. Herd immunity was simulated in an alternative base-case scenario and sensitivity analyses. RESULTS: In the base-case analysis without herd immunity and with all cohorts vaccinated, at € 40 per vaccine dose, routine infant vaccination would provide the lowest cost per QALY gained (€ 380,973) despite only preventing 18% of cases. Under the assumption of herd immunity, the adolescent vaccination would provide the lowest cost per QALY gained (€ 135,902) preventing 24% of cases. Infant vaccination with a late booster and catch-up would prevent 51% of cases with a cost of € 188,511 per QALY gained. CONCLUSIONS: Given current meningococcal epidemiology in France and the available data on the protection provided by Bexsero(®), our modelling work showed that routine vaccination against serogroup B meningococcal disease is not cost-effective.
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-02058985
Contributor : Marie Martin <>
Submitted on : Wednesday, March 6, 2019 - 12:13:34 PM
Last modification on : Tuesday, September 22, 2020 - 10:00:03 AM

Identifiers

Collections

Citation

Héloïse Lecocq, Isabelle Parent Du Châtelet, Muhamed-Kheir Taha, Daniel Levy-Bruhl, Benoît Dervaux. Epidemiological impact and cost-effectiveness of introducing vaccination against serogroup B meningococcal disease in France.. Vaccine, Elsevier, 2016, 34 (19), pp.2240-2250. ⟨10.1016/j.vaccine.2016.03.020⟩. ⟨pasteur-02058985⟩

Share

Metrics

Record views

56