Intravital imaging of host-parasite interactions in skin and adipose tissues

Mariana de Niz (1, 2) , Gavin R Meehan (2) , Nicolas M.B. Brancucci (3) , Matthias Marti (2) , Brice Rotureau (4) , Luisa Figueiredo (5) , Friedrich Frischknecht (6)

1 UNIBE - Universität Bern / University of Bern
2 University of Glasgow
3 Swiss Tropical and Public Health Institute [Basel]
4 Biologie cellulaire des Trypanosomes - Trypanosome Cell Biology
5 ULISBOA - Universidade de Lisboa = University of Lisbon
6 Heidelberg University Hospital [Heidelberg]

Intravital microscopy (IVM) allows the visualization of how pathogens interact with host cells and tissues in living animals in real time. This method has enabled key advances in our understanding of host-parasite interactions under physiological conditions. A combination of genetics, microscopy techniques and image analysis have recently facilitated the understanding of biological phenomena in living animals at cellular and sub-cellular resolution. In this review, we summarize findings achieved by intravital microscopy of the skin and adipose tissues upon infection with various parasites and we present a view into possible future applications of this method.

Domaines: Parasitologie; Biotechnologies

Mariana de Niz, Gavin R Meehan, Nicolas M.B. Brancucci, Matthias Marti, Brice Rotureau, et al.. Intravital imaging of host-parasite interactions in skin and adipose tissues. Cellular Microbiology, 2019, pp.e13023. ⟨10.1111/cmi.13023⟩. ⟨pasteur-02057198⟩