Integrated view of Vibrio cholerae in the Americas

Daryl Domman (1) , Marie-Laure Quilici (2) , Matthew Dorman (1) , Elisabeth Njamkepo (2) , Ankur Mutreja (3, 1) , Alison Mather (1, 3) , Gabriella Delgado (4) , Rosario Morales-Espinosa (4) , Patrick A. D. Grimont (5) , Marcial Leonardo Lizárraga-Partida (6) , Christiane Bouchier (7) , David Aanensen (1) , Pablo Kuri-Morales (8) , Cheryl Tarr (9) , Gordon Dougan (1, 3) , Julian Parkhill (1) , Josefina Campos (10) , Alejandro S Cravioto (4) , François-Xavier Weill (1, 2) , Nicholas Thomson (1, 11)

1 The Wellcome Trust Sanger Institute [Cambridge]
2 BPE - Bactéries pathogènes entériques
3 CAM - University of Cambridge [UK]
4 UNAM - Universidad Nacional Autónoma de México = National Autonomous University of Mexico
5 Biodiversité des Bactéries Pathogènes Émergentes
6 CICESE - Centro de Investigacion Cientifica y de Education Superior de Ensenada [Mexico]
7 Génomique (Plate-Forme) - Genomics Platform
8 Secretaría de Salud, Mexico city
9 CDC - Centers for Disease Control and Prevention [Atlanta]
10 ANLIS - Administración Nacional de Laboratorios e Institutos de Salud ‘Carlos Malbran'
11 LSHTM - London School of Hygiene and Tropical Medicine

Latin America has experienced two of the largest cholera epidemics in modern history; one in 1991 and the other in 2010. However, confusion still surrounds the relationships between globally circulating pandemic Vibrio cholerae clones and local bacterial populations. We used whole-genome sequencing to characterize cholera across the Americas over a 40-year time span. We found that both epidemics were the result of intercontinental introductions of seventh pandemic El Tor V. cholerae and that at least seven lineages local to the Americas are associated with disease that differs epidemiologically from epidemic cholera. Our results consolidate historical accounts of pandemic cholera with data to show the importance of local lineages, presenting an integrated view of cholera that is important to the design of future disease control strategies.

Domaines: Santé publique et épidémiologie; Microbiologie et Parasitologie

Daryl Domman, Marie-Laure Quilici, Matthew Dorman, Elisabeth Njamkepo, Ankur Mutreja, et al.. Integrated view of Vibrio cholerae in the Americas. Science, 2017, 358 (6364), pp.789-793. ⟨10.1126/science.aao2136⟩. ⟨pasteur-02046343⟩