Type VII secretion system of mycobacteria show the way, Nat. Rev. Microbiol, vol.5, pp.883-891, 2007. ,
ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis, Cell Microbiol, vol.15, 1994. ,
Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis, Nat. Commun, vol.8, p.16085, 2017. ,
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis, Science, vol.307, pp.223-227, 2005. ,
Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes, J. Exp. Med, vol.134, pp.713-740, 1971. ,
Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids, PLOS Pathog, vol.5, p.1000289, 2009. ,
The mannose receptor mediates uptake of pathogenic and nonpathogenic mycobacteria and bypasses bactericidal responses in human macrophages, Infect. Immun, vol.67, pp.469-477, 1999. ,
URL : https://hal.archives-ouvertes.fr/hal-00178911
ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis, Cell Microbiol, vol.19, p.12726, 2017. ,
Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide, Cell Microbiol, vol.10, pp.1530-1545, 2008. ,
TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis, J. Exp. Med, vol.202, pp.1715-1724, 2005. ,
Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence, PLOS Pathog, vol.13, p.1006363, 2017. ,
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies, Nat. Rev. Microbiol, vol.7, pp.845-855, 2009. ,
Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis, Nat. Microbiol, vol.2, p.17047, 2017. ,
Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy?, Nat. Rev. Microbiol, vol.8, pp.668-674, 2010. ,
Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis, Mucosal Immunol, vol.4, pp.279-287, 2011. ,
pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence, Nat. Microbiol, vol.1, p.15019, 2016. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01265519
Striking the right balance determines TB or not TB, Front. Immunol, vol.5, p.455, 2014. ,
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation, Mol. Microbiol, vol.83, pp.1195-1209, 2012. ,
Increased protective efficacy of recombinant BCG strains expressing virulenceneutral proteins of the ESX-1 secretion system, Vaccine, vol.33, pp.2710-2718, 2015. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01182937
Targeting type VII/ESX secretion systems for development of novel antimycobacterial drugs, Curr. Pharm. Des, vol.20, pp.4346-4356, 2014. ,
MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis, PLOS Pathog, vol.5, p.1000474, 2009. ,
The envelope of mycobacteria, Annu. Rev. Biochem, vol.64, pp.29-63, 1995. ,
Host evasion and exploitation schemes of Mycobacterium tuberculosis, Cell, vol.159, pp.1497-1509, 2014. ,
Phenolic glycolipid facilitates mycobacterial escape from microbicidal tissue-resident macrophages, Immunity, vol.47, 2017. ,
MmpL transporter-mediated export of cell-wall associated lipids and siderophores in mycobacteria, Tuberculosis, vol.100, pp.32-45, 2016. ,
Towards anti-virulence drugs targeting ESX-1 mediated pathogenesis of Mycobacterium tuberculosis, Drug Discov. Today, vol.7, pp.25-31, 2010. ,
High content screening identifies decaprenylphosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors, PLOS Pathog, vol.5, p.1000645, 2009. ,
Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited, J. Exp. Med, vol.181, pp.257-270, 1995. ,
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence, Nature, vol.393, pp.537-544, 1998. ,
Cyclic GMP-AMP synthase is an innate immune DNA sensor for Mycobacterium tuberculosis, Cell Host Microbe, vol.17, pp.820-828, 2015. ,
Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions, Proc. Natl. Acad. Sci. U.S.A, vol.114, pp.1371-1376, 2017. ,
Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes, Proc. Natl. Acad. Sci. U.S.A, vol.108, pp.19484-19491, 2011. ,
Genetics of capsular polysaccharides and cell envelope (Glyco)lipids. Microbiol. Spectr. 2, 14, 2014. ,
M. tuberculosis-induced necrosis of infected neutrophils promotes bacterial growth following phagocytosis by macrophages, Cell Host Microbe, vol.22, pp.519-530, 2017. ,
The role of the granuloma in expansion and dissemination of early tuberculous infection, Cell, vol.136, pp.37-49, 2009. ,
The diarylquinoline TMC207 for multidrug-resistant tuberculosis, N. Engl. J. Med, vol.360, pp.2397-2405, 2009. ,
Revisiting the structure of the anti-neoplastic glucans of Mycobacterium bovis Bacille Calmette-Guerin. Structural analysis of the extracellular and boiling water extract-derived glucans of the vaccine substrains, J. Biol. Chem, vol.279, pp.12369-12378, 2004. ,
Mycobacterial survival strategies in the phagosome: defence against host stresses, Cell Microbiol, vol.11, pp.1170-1178, 2009. ,
Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest, J. Cell Biol, vol.154, pp.631-644, 2001. ,
Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest, Proc. Natl. Acad. Sci. U.S.A, vol.100, pp.5437-5442, 2003. ,
Deletion of nuoG from the vaccine candidate Mycobacterium bovis BCG DeltaureC::hly improves protection against tuberculosis, vol.7, pp.679-695, 2016. ,
Recombinant BCG expressing ESX-1 of Mycobacterium marinum combines low virulence with cytosolic immune signaling and improved TB protection, Cell Rep, vol.18, pp.2752-2765, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01503927
ESX secretion systems: mycobacterial evolution to counter host immunity, Nat. Rev. Microbiol, vol.14, pp.677-691, 2016. ,
Mechanisms of pathogen entry through the endosomal compartments, Nat. Rev. Mol. Cell Biol, vol.7, pp.495-504, 2006. ,
Functional role(s) of phagosomal Rab GTPases, Small GTPases, vol.4, pp.148-158, 2013. ,
ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria, Cell Microbiol, vol.14, pp.1287-1298, 2012. ,
Autophagy as a basis for the health-promoting effects of vitamin D, Trends Mol. Med, vol.16, pp.295-302, 2010. ,
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle, J. Exp. Med, vol.206, pp.2879-2888, 2009. ,
Mycobacterial escape from macrophage phagosomes to the cytoplasm represents an alternate adaptation mechanism, Sci. Rep, vol.6, p.23089, 2016. ,
Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin, Cell, vol.130, pp.37-50, 2007. ,
The carbonic anhydrase inhibitor ethoxzolamide inhibits the Mycobacterium tuberculosis PhoPR regulon and Esx-1 secretion and attenuates virulence, Antimicrob. Agents Chemother, vol.59, pp.4436-4445, 2015. ,
The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis, J. Exp. Med, vol.202, pp.987-999, 2005. ,
Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34, Proc. Natl. Acad. Sci. U.S.A, vol.109, pp.20485-20490, 2012. ,
ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo, J. Clin. Invest, vol.126, pp.2109-2122, 2016. ,
Manipulation of host cell death pathways during microbial infections, Cell Host Microbe, vol.8, pp.44-54, 2010. ,
Revisiting the role of phospholipases C in the virulence of Mycobacterium tuberculosis, Sci. Rep, vol.5, p.16918, 2015. ,
Phagosomal membranes of Mycobacterium bovis BCG-immune alveolar macrophages are resistant to disruption by Mycobacterium tuberculosis H37Rv, Infect. Immun, vol.45, pp.443-446, 1984. ,
Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages, PLOS ONE, vol.6, 2011. ,
Mycobacterium tuberculosis replicates within necrotic human macrophages, J. Cell Biol, vol.216, pp.583-594, 2017. ,
Tolllike receptor triggering of a vitamin D-mediated human antimicrobial response, Science, vol.311, pp.1770-1773, 2006. ,
Statins increase rifampin mycobactericidal effect, Antimicrob. Agents Chemother, vol.58, pp.5766-5774, 2014. ,
C-type lectins with a sweet spot for Mycobacterium tuberculosis, Eur. J. Microbiol. Immunol, vol.1, pp.25-40, 2011. ,
Mycobacterium tuberculosis meets the cytosol: the role of cGAS in anti-mycobacterial immunity, Cell Host Microbe, vol.17, pp.733-735, 2015. ,
The ubiquitin ligase parkin mediates resistance to intracellular pathogens, Nature, vol.501, pp.512-516, 2013. ,
Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages, Cell Host Microbe, vol.11, pp.469-480, 2012. ,
MTBVAC from discovery to clinical trials in tuberculosis-endemic countries, Expert Rev. Vaccines, vol.16, pp.565-576, 2017. ,
Pathogenesis of tuberculosis: interaction of Mycobacterium tuberculosis with macrophages, Infect. Immun, vol.61, pp.2763-2773, 1993. ,
Pattern recognition receptors and coordinated cellular pathways involved in tuberculosis immunopathogenesis: emerging concepts and perspectives, Mol. Immunol, vol.87, pp.240-248, 2017. ,
Interaction of pattern recognition receptors with Mycobacterium tuberculosis, J. Clin. Immunol, vol.35, pp.1-10, 2015. ,
Disruption of phagosomal membranes of normal alveolar macrophages by the H37Rv strain of Mycobacterium tuberculosis. A correlate of virulence, Am. Rev. Respir. Dis, vol.129, pp.322-328, 1984. ,
Mannosylated lipoarabinomannans inhibit IL-12 production by human dendritic cells: evidence for a negative signal delivered through the mannose receptor, J. Immunol, vol.166, pp.7477-7485, 2001. ,
URL : https://hal.archives-ouvertes.fr/hal-00177977
The immune response in tuberculosis, Annu. Rev. Immunol, vol.31, pp.475-527, 2013. ,
The balance between protective and pathogenic immune responses in the TB-infected lung, Nat. Immunol, vol.16, pp.57-63, 2015. ,
Statin therapy reduces the Mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation, J. Infect. Dis, vol.209, pp.754-763, 2014. ,
Multiple deletions in the polyketide synthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen interactions, Cell Microbiol, vol.16, pp.195-213, 2014. ,
Trehalose dimycolate interferes with FcgammaR-mediated phagosome maturation through Mincle, SHP-1 and FcgammaRIIB signalling, PLOS ONE, vol.12, 2017. ,
Epidemiology: a mortal foe, Nature, vol.502, 2013. ,
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis, Nat. Med, vol.19, pp.1157-1160, 2013. ,
Rab GTPases in immunity and inflammation, Front. Cell Infect. Microbiol, vol.7, p.435, 2017. ,
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti, Mol. Microbiol, vol.46, pp.709-717, 2002. ,
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis, Nat. Med, vol.9, pp.533-539, 2003. ,
Toll-like receptor pathways in the immune responses to mycobacteria, Microbes Infect, vol.6, pp.946-959, 2004. ,
Mycobacterium tuberculosis controls phagosomal acidification by targeting CISH-mediated signalling, Cell Rep, vol.20, pp.3188-3198, 2017. ,
The cell wall lipid PDIM contributes to phagosomal escape and host cell exit of Mycobacterium tuberculosis, vol.8, pp.148-165, 2017. ,
ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells, Autophagy, vol.8, pp.1357-1370, 2012. ,
The ins and outs of the Mycobacterium tuberculosiscontaining vacuole, Cell Microbiol, vol.18, pp.1065-1069, 2016. ,
Foamy macrophages and the progression of the human tuberculosis granuloma, Nat. Immunol, vol.10, pp.943-948, 2009. ,
Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion, Cell Host Microbe, vol.16, pp.538-548, 2014. ,
Ubiquilin 1 promotes IFN-gamma-induced xenophagy of Mycobacterium tuberculosis, PLOS Pathog, vol.11, 2015. ,
Toll-like receptor signaling and its inducible proteins, Microbiol. Spectr, vol.4, 2016. ,
CD4+ T cells recognizing PE/PPE antigens directly or via cross reactivity are protective against pulmonary Mycobacterium tuberculosis infection, PLOS Pathog, vol.12, p.1005770, 2016. ,
Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 Type VII secretion-encoded PE-PPE proteins predicts vaccine potential, Cell Host Microbe, vol.11, pp.352-363, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01104794
A Rab20-Dependent membrane trafficking pathway controls M. tuberculosis replication by regulating phagosome spaciousness and integrity, Cell Host Microbe, vol.21, 2017. ,
Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death, PLOS Pathog, vol.8, p.1002507, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01899479
Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access, Cell Microbiol, vol.18, pp.1070-1077, 2016. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01899438
, , 2015.
, Cytosolic Access of Mycobacterium tuberculosis: critical impact of phagosomal acidification control and demonstration of occurrence in vivo, PLOS Pathog, vol.11, p.1004650
Simvastatin increases the in vivo activity of the first-line tuberculosis regimen, J. Antimicrob. Chemother, vol.69, pp.2453-2457, 2014. ,
Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase, Science, vol.263, pp.678-681, 1994. ,
Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification, J. Cell Sci, vol.122, pp.2504-2513, 2009. ,
How is the phagocyte lectin keyboard played? Master class lesson by Mycobacterium tuberculosis, Trends Microbiol, vol.11, pp.102-103, 2003. ,
C-type lectins in immune defense against pathogens: the murine DC-SIGN homologue SIGNR3 confers early protection against Mycobacterium tuberculosis infection, Virulence, vol.1, pp.285-290, 2010. ,
Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion, Nature, vol.482, pp.414-418, 2012. ,
Host-directed therapies for tuberculosis. Cold Spring Harb, Perspect. Med, vol.5, p.21196, 2015. ,
Cytokines in the balance of protection and pathology during mycobacterial infections, Adv. Exp. Med. Biol, vol.783, pp.121-140, 2013. ,
C-Type lectin receptor DCAR recognizes mycobacterial phosphatidyl-inositol mannosides to promote a Th1 response during infection, Immunity, vol.45, pp.1245-1257, 2016. ,
Direct delivery of procathepsin D to phagosomes: implications for phagosome biogenesis and parasitism by Mycobacterium, Eur. J. Cell Biol, vol.78, issue.99, pp.80042-80051, 1999. ,
New insights into the function of granulomas in human tuberculosis, J. Pathol, vol.208, pp.261-269, 2006. ,
Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1, J. Leukoc. Biol, vol.88, pp.227-232, 2010. ,
M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells, Cell, vol.129, pp.1287-1298, 2007. ,
XDR tuberculosis: an indicator of public-health negligence, Lancet, vol.368, pp.69575-69580, 2006. ,
Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment, PLOS Pathog, vol.11, 2015. ,
The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages, Sci. Rep, vol.6, p.29332, 2016. ,
Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells, PLOS Pathog, vol.3, p.110, 2007. ,
Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis, Proc. Natl. Acad. Sci. U.S.A, vol.102, pp.4033-4038, 2005. ,
Mycobacterium tuberculosis phagosome maturation arrest: mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusion, Mol. Biol. Cell, vol.15, pp.751-760, 2004. ,
Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7, J. Biol. Chem, vol.272, pp.13326-13331, 1997. ,
Phagosome maturation: aging gracefully, Biochem. J, vol.366, pp.689-704, 2002. ,
Mycobacteria use their surface-exposed glycolipids to infect human macrophages through a receptor-dependent process, J. Lipid Res, vol.46, pp.475-483, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00078727
Advancing host-directed therapy for tuberculosis, Nat. Rev. Immunol, vol.15, pp.255-263, 2015. ,
The survival kit of Mycobacterium tuberculosis, Nat. Med, vol.13, pp.282-284, 2007. ,
Mycobacterium tuberculosis differentially activates cGAS-and inflammasome-dependent intracellular immune responses through ESX-1, Cell Host Microbe, vol.17, pp.799-810, 2015. ,
The cytosolic sensor cGAS Detects Mycobacterium tuberculosis DNA to induce type I interferons and activate autophagy, Cell Host Microbe, vol.17, pp.811-819, 2015. ,
Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway, Cell, vol.150, pp.803-815, 2012. ,
All-trans retinoic acid-triggered antimicrobial activity against Mycobacterium tuberculosis is dependent on NPC2, J. Immunol, vol.192, pp.2280-2290, 2014. ,
, WHO, 2016.
Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+ATPase to inhibit phagosome acidification, Proc. Natl. Acad. Sci. U.S.A, vol.108, pp.19371-19376, 2011. ,
Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis, Cell Microbiol, vol.13, pp.1371-1384, 2011. ,
Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages, J. Immunol, vol.153, pp.2568-2578, 1994. ,
Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria, Immunity, vol.41, pp.402-413, 2014. ,
Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin, Cell Host Microbe, vol.6, pp.231-243, 2009. ,
Polymorphic allele of human MRC1 confer protection against tuberculosis in a Chinese population, Int. J. Biol. Sci, vol.8, pp.375-382, 2012. ,
Towards host-directed therapies for tuberculosis, Nat. Rev. Drug Discov, vol.14, pp.511-512, 2015. ,