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Genomic history of the seventh pandemic of cholera in Africa

François-Xavier Weill 1, 2, * Daryl Domman 2 Elisabeth Njamkepo 1 Cheryl Tarr 3 Jean Rauzier 1 Nizar Fawal 1 Karen H. Keddy 4, 5 Henrik Salje 6, 7 Sandra Moore 8, 9 Asish Mukhopadhyay 9, 8 Raymond Bercion 10, 11 Francisco J. Luquero 12 Antoinette Ngandjio 13 Mireille Dosso 14 Elena Monakhova 15 Benoit Garin 11 Christiane Bouchier 16 Carlo Pazzani 17 Ankur Mutreja 18, 19 Roland Grunow 20 Fati Sidikou 21 Laurence Bonte 12 Sebastien Breurec 10 Maria Damian 22 Berthe-Marie Njanpop-Lafourcade 23 Guillaume Sapriel 24, 25 Anne-Laure Page 12 Monzer Hamze 26 Myriam Henkens 27 Goutam Chowdhury 28 Martin Mengel 23 Jean-Louis Koeck 29 Jean-Michel Fournier 30 Gordon Dougan 2, 18 Patrick A. D. Grimont 31 Julian Parkhill 2 Kathryn E. Holt 32 Renaud Piarroux 8, 9 Thandavarayan Ramamurthy 19 Marie Laure Quilici 30 Nicholas R Thomson 2, 33
* Corresponding author
Abstract : The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.
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Submitted on : Friday, February 22, 2019 - 11:51:18 AM
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François-Xavier Weill, Daryl Domman, Elisabeth Njamkepo, Cheryl Tarr, Jean Rauzier, et al.. Genomic history of the seventh pandemic of cholera in Africa. Science, American Association for the Advancement of Science, 2017, 358 (6364), pp.785-789. ⟨10.1126/science.aad5901⟩. ⟨pasteur-02045755⟩

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