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Journal articles
Aranazoles: Extensively Chlorinated Nonribosomal Peptide-Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339
Abstract : An analysis of cyanobacterial genomes revealed an architecturally unique biosynthetic gene cluster with an unusually high number of genes encoding predicted iron(II)/α-ketoglutarate-dependent halogenases. Mass spectrometry-guided identification of the corresponding metabolites yielded the aranazoles, extensively halogenated nonribosomal peptide− polyketide hybrids. Their chlorine-bearing fatty acyl-like moiety is reminiscent of the hyperhalogenated chlorosulfolipids, natural products of unknown enzymatic origin that were previously isolated from eukaryotic algae and mussels.
Cited literature [1 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02044692
Contributor : Bénédicte Benedic <>
Submitted on : Thursday, February 21, 2019 - 3:56:19 PM
Last modification on : Monday, January 13, 2020 - 5:08:19 PM
Contributor : Bénédicte Benedic <>
Submitted on : Thursday, February 21, 2019 - 3:56:19 PM
Last modification on : Monday, January 13, 2020 - 5:08:19 PM