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Aranazoles: Extensively Chlorinated Nonribosomal Peptide-Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339

Abstract : An analysis of cyanobacterial genomes revealed an architecturally unique biosynthetic gene cluster with an unusually high number of genes encoding predicted iron(II)/α-ketoglutarate-dependent halogenases. Mass spectrometry-guided identification of the corresponding metabolites yielded the aranazoles, extensively halogenated nonribosomal peptide− polyketide hybrids. Their chlorine-bearing fatty acyl-like moiety is reminiscent of the hyperhalogenated chlorosulfolipids, natural products of unknown enzymatic origin that were previously isolated from eukaryotic algae and mussels.
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Submitted on : Thursday, February 21, 2019 - 3:56:19 PM
Last modification on : Monday, January 13, 2020 - 5:08:19 PM

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Philipp Moosmann, Reiko Ueoka, Muriel Gugger, Jörn Piel. Aranazoles: Extensively Chlorinated Nonribosomal Peptide-Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339. Organic Letters, American Chemical Society, 2018, 20 (17), pp.5238-5241. ⟨10.1021/acs.orglett.8b02193⟩. ⟨pasteur-02044692⟩

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