Skip to Main content Skip to Navigation
Journal articles

Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events

Vanessa Wong 1, 2, * Stephen Baker 3, 4, 5 Derek Pickard 1 Julian Parkhill 1 Andrew Page 1 Nicholas Feasey 6 Robert Kingsley 1, 7 Nicholas Thomson 1, 5 Jacqueline Keane 1 François-Xavier Weill 8 David Edwards 9 Jane Hawkey 9 Simon Harris 1 Alison Mather 1 Amy Cain 1 James Hadfield 1 Peter Hart 10 Nga Tran Vu Thieu 3 Elizabeth Klemm 1 Dafni Glinos 1 Robert Breiman 11, 12, 13 Conall Watson 5 Samuel Kariuki 1, 11 Melita Gordon 14 Robert Heyderman 15 Chinyere Okoro 1 Jan Jacobs 16, 17 Octavie Lunguya 18, 19 W John Edmunds 5 Chisomo Msefula 15 José Chabalgoity 20 Mike Kama 21 Kylie Jenkins 21 Shanta Dutta 22 Florian Marks 23 Josefina Campos 24 Corinne Thompson 3, 4 Stephen Obaro 25, 26, 27 Calman Maclennan 1, 10, 28 Christiane Dolecek 4 Karen Keddy 29 Anthony Smith 29 Christopher Parry 5, 30 Abhilasha Karkey 3 E Kim Mulholland 5, 31 James Campbell 3, 4 Sabina Dongol 32 Buddha Basnyat 32 Muriel Dufour 33 Don Bandaranayake 33 Take Toleafoa Naseri 34 Shalini Pravin Singh 35 Mochammad Hatta 36 Paul Newton 37, 4 Robert Onsare 11 Lupeoletalalei Isaia 38 David Dance 37, 4 Viengmon Davong 37 Guy Thwaites 3, 4 Lalith Wijedoru 39, 40 John Crump 41 Elizabeth de Pinna 42 Satheesh Nair 42 Eric Nilles 35 Duy Pham Thanh 3 Paul Turner 39, 4, 43 Sona Soeng 43 Mary Valcanis 44 Joan Powling 44 Karolina Dimovski 44 Geoff Hogg 44 Jeremy Farrar 3, 4 Kathryn Holt 9 Gordon Dougan 1
* Corresponding author
Abstract : The emergence of multidrug-resistant (MDR) typhoid is a major global health threat affecting many countries where the disease is endemic. Here whole-genome sequence analysis of 1,832 Salmonella enterica serovar Typhi (S. Typhi) identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years. Our analysis identifies numerous transmissions of H58, including multiple transfers from Asia to Africa and an ongoing, unrecognized MDR epidemic within Africa itself. Notably, our analysis indicates that H58 lineages are displacing antibiotic-sensitive isolates, transforming the global population structure of this pathogen. H58 isolates can harbor a complex MDR element residing either on transmissible IncHI1 plasmids or within multiple chromosomal integration sites. We also identify new mutations that define the H58 lineage. This phylogeographical analysis provides a framework to facilitate global management of MDR typhoid and is applicable to similar MDR lineages emerging in other bacterial species.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-02043698
Contributor : Fanny Sebire <>
Submitted on : Thursday, February 21, 2019 - 10:54:15 AM
Last modification on : Thursday, June 18, 2020 - 4:48:05 PM

Links full text

Identifiers

Collections

Citation

Vanessa Wong, Stephen Baker, Derek Pickard, Julian Parkhill, Andrew Page, et al.. Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events. Nature Genetics, Nature Publishing Group, 2015, 47 (6), pp.632-639. ⟨10.1038/ng.3281⟩. ⟨pasteur-02043698⟩

Share

Metrics

Record views

115