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Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project

Marianne Oldehinkel 1, 2, 3, * Maarten Mennes 3 Andre Marquand 1, 3, 4 Tony Charman 4 Julian Tillmann 4 Christine Ecker 4 Flavio Dell'Acqua 4, 5 Daniel Brandeis 6, 7, 8 Tobias Banaschewski 9 Sarah Baumeister 6 Carolin Moessnang 6 Simon Baron-Cohen 10 Rosemary Holt 10 Sven Bölte 11, 12 Sarah Durston 13 Prantik Kundu 14 Michael Lombardo 10, 15 Will Spooren 16 Eva Loth 4 Declan Murphy 4 Christian Beckmann 1, 3, 17 Jan Buitelaar 1, 3 Jumana Ahmad 4 Sara Ambrosino 13 Bonnie Auyeung 18 Thomas Bourgeron 19 Carsten Bours 1 Michael Brammer 4 Claudia Brogna 20 Yvette de Bruijn 1 Bhismadev Chakrabarti 21 Ineke Cornelissen 1 Daisy Crawley 4 Flavio Dell’acqua 4 Guillaume Dumas 19 Jessica Faulkner Vincent Frouin Pilar Garcés 16 David Goyard 22 Lindsay Ham 23 Hannah Hayward Joerg Hipp 16 Mark Johnson 24 Emily J.H. Jones Meng-Chuan Lai 25 Xavier Liogier D’ardhuy David Lythgoe 4 René Mandl 13 Luke Mason 26 Andre Meyer-Lindenberg Nico Mueller Declan G.M. Murphy Bethany Oakley Laurence O’dwyer 1 Bob Oranje 13 Gahan Pandina 27 Antonio Persico 20 Barbara Ruggeri 4 Amber Ruigrok 10 Jessica Sabet 4 Roberto Sacco Antonia San José Cáceres Simon Simonoff Roberto Toro 19 Heike Tost 6 Jack Waldman 10 Steven C.R. Williams Caroline Wooldridge Marcel Zwiers 1
* Corresponding author
1 Radboud University Medical Center [Nijmegen]
2 Monash University [Melbourne]
3 Donders Institute for Brain, Cognition and Behaviour
4 Institute of Psychiatry, Psychology & Neuroscience, King's College London
5 Goethe-University Frankfurt am Main
6 Universität Heidelberg [Heidelberg]
7 UZH - University of Zürich [Zürich]
8 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
9 Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim]
10 CAM - University of Cambridge [UK]
11 Karolinska Institutet [Stockholm]
12 Stockholm County Council
13 University Medical Center [Utrecht]
14 MSSM - Icahn School of Medicine at Mount Sinai [New York]
15 University of Cyprus [Nicosia]
16 pRED - Roche Pharma Research and Early Development [Basel]
17 University of Oxford [Oxford]
18 University of Edinburgh
19 GHFC (UMR_3571 / U-Pasteur_1) - Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions
20 UCBM - Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome
21 UOR - University of Reading
22 DCM - Département de Chimie Moléculaire
23 F. Hoffmann-La Roche [Basel]
24 UON - University of Nottingham, UK
25 University of Toronto
26 Centre for Brain and Cognitive Development [Birkbeck College]
27 Janssen Research & Development
Abstract : BACKGROUND: Resting-state functional magnetic resonance imaging-based studies on functional connectivity in autism spectrum disorder (ASD) have generated inconsistent results. Interpretation of findings is further hampered by small samples and a focus on a limited number of networks, with networks underlying sensory processing being largely underexamined. We aimed to comprehensively characterize ASD-related alterations within and between 20 well-characterized resting-state networks using baseline data from the EU-AIMS (European Autism Interventions-A Multicentre Study for Developing New Medications) Longitudinal European Autism Project. METHODS: Resting-state functional magnetic resonance imaging data was available for 265 individuals with ASD (7.5-30.3 years; 73.2% male) and 218 typically developing individuals (6.9-29.8 years; 64.2% male), all with IQ > 70. We compared functional connectivity within 20 networks-obtained using independent component analysis-between the ASD and typically developing groups, and related functional connectivity within these networks to continuous (overall) autism trait severity scores derived from the Social Responsiveness Scale Second Edition across all participants. Furthermore, we investigated case-control differences and autism trait-related alterations in between-network connectivity. RESULTS: Higher autism traits were associated with increased connectivity within salience, medial motor, and orbitofrontal networks. However, we did not replicate previously reported case-control differences within these networks. The between-network analysis did reveal case-control differences showing on average 1) decreased connectivity of the visual association network with somatosensory, medial, and lateral motor networks, and 2) increased connectivity of the cerebellum with these sensory and motor networks in ASD compared with typically developing subjects. CONCLUSIONS: We demonstrate ASD-related alterations in within- and between-network connectivity. The between-network alterations broadly affect connectivity between cerebellum, visual, and sensory-motor networks, potentially underlying impairments in multisensory and visual-motor integration frequently observed in ASD.
Keywords : Autism Cerebellum Functional connectivity Resting-state fMRI Sensory networks Visual-motor integration
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02029576
Contributor : Fanny Sebire <>
Submitted on : Wednesday, February 20, 2019 - 10:29:45 AM
Last modification on : Thursday, May 27, 2021 - 1:54:06 PM

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Marianne Oldehinkel, Maarten Mennes, Andre Marquand, Tony Charman, Julian Tillmann, et al.. Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Elsevier, 2018, ⟨10.1016/j.bpsc.2018.11.010⟩. ⟨pasteur-02029576⟩

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