Mitotic bookmarking in development and stem cells - Institut Pasteur Access content directly
Journal Articles Development (Cambridge, England) Year : 2017

Mitotic bookmarking in development and stem cells

Abstract

The changes imposed on the nucleus, chromatin and its regulators during mitosis lead to the dismantlement of most gene regulatory processes. However, an increasing number of transcriptional regulators are being identified as capable of binding their genomic targets during mitosis. These so-called 'mitotic bookmarking factors' encompass transcription factors and chromatin modifiers that are believed to convey gene regulatory information from mother to daughter cells. In this Primer, we review mitotic bookmarking processes in development and stem cells and discuss the interest and potential importance of this concept with regard to epigenetic regulation and cell fate transitions involving cellular proliferation.
Fichier principal
Vignette du fichier
3633.full.pdf (1.07 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

pasteur-02024822 , version 1 (19-02-2019)

Licence

Copyright

Identifiers

Cite

Nicola Festuccia, Inma González, Nick Owens, Pablo Navarro Gil. Mitotic bookmarking in development and stem cells. Development (Cambridge, England), 2017, 144 (20), pp.3633-3645. ⟨10.1242/dev.146522⟩. ⟨pasteur-02024822⟩
66 View
356 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More