Skip to Main content Skip to Navigation
Journal articles

Emergence of meningococci with reduced susceptibility to third-generation cephalosporins.

Abstract : OBJECTIVES: Reduced susceptibility to penicillin G in Neisseria meningitidis is mainly due to alterations in PBP2 encoded by the penA gene. However, this phenotype was not associated with reduced susceptibility to third-generation cephalosporins (C3Gs). We aimed to study the emergence of meningococci with reduced susceptibility to C3Gs (MIC >0.06 mg/L) in France since 2012. METHODS: Invasive meningococcal isolates were typed by MLST and penA sequencing and their antibiotic susceptibility was tested. RESULTS: Isolates with reduced susceptibility to C3Gs represented 2% of all invasive isolates from 2012-15, but were absent before. They harboured a new penA allele, penA327, that was also detected in isolates from urethritis cases and in gonococci. CONCLUSIONS: Surveillance of these isolates should be enhanced as they may jeopardize the use of C3Gs in the management of invasive meningococcal disease.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-02013247
Contributor : Muhamed-Kheir Taha <>
Submitted on : Friday, April 26, 2019 - 11:05:35 AM
Last modification on : Monday, January 13, 2020 - 5:08:15 PM

Links full text

Identifiers

Collections

Citation

Ala-Eddine Deghmane, Eva Hong, Muhamed-Kheir Taha. Emergence of meningococci with reduced susceptibility to third-generation cephalosporins.. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2017, 72 (1), pp.95-98. ⟨10.1093/jac/dkw400⟩. ⟨pasteur-02013247⟩

Share

Metrics

Record views

111