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Journal articles
Emergence of meningococci with reduced susceptibility to third-generation cephalosporins.
Abstract : OBJECTIVES:
Reduced susceptibility to penicillin G in Neisseria meningitidis is mainly due to alterations in PBP2 encoded by the penA gene. However, this phenotype was not associated with reduced susceptibility to third-generation cephalosporins (C3Gs). We aimed to study the emergence of meningococci with reduced susceptibility to C3Gs (MIC >0.06 mg/L) in France since 2012.
METHODS:
Invasive meningococcal isolates were typed by MLST and penA sequencing and their antibiotic susceptibility was tested.
RESULTS:
Isolates with reduced susceptibility to C3Gs represented 2% of all invasive isolates from 2012-15, but were absent before. They harboured a new penA allele, penA327, that was also detected in isolates from urethritis cases and in gonococci.
CONCLUSIONS:
Surveillance of these isolates should be enhanced as they may jeopardize the use of C3Gs in the management of invasive meningococcal disease.
https://hal-pasteur.archives-ouvertes.fr/pasteur-02013247
Contributor : Muhamed-Kheir Taha <>
Submitted on : Friday, April 26, 2019 - 11:05:35 AM
Last modification on : Monday, January 13, 2020 - 5:08:15 PM
Contributor : Muhamed-Kheir Taha <>
Submitted on : Friday, April 26, 2019 - 11:05:35 AM
Last modification on : Monday, January 13, 2020 - 5:08:15 PM
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