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The Global Meningococcal Initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection.

Ray Borrow 1, * Pedro Alarcón 2 Josefina Carlos 3 Dominique A Caugant 4 Hannah Christensen 5 Roberto Debbag 6 Philippe de Wals 7 Gabriela Echániz-Aviles 8 Jamie Findlow 1 Chris Head 9 Daphne Head 10 Hajime Kamiya 11 Samir K. Saha 12 Sergey Sidorenko 13 Muhamed-Kheir Taha 14 Caroline Trotter 15 Julio Carlos 16 Anne von Gottberg 17 Marco Sáfadi 18 
Abstract : The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology. Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisseria meningitidis serogroup [Men]C in Brazil, MenA in the African meningitis belt), new clones have emerged, causing outbreaks (e.g. MenW in South America, MenC in Nigeria and Niger). The importance of herd protection was highlighted, emphasizing the need for high vaccination uptake among those with the highest carriage rates, as was the need for boosters to maintain individual and herd protection following decline of immune response after primary immunization. Expert commentary: The GMI Global Recommendations for Meningococcal Disease were updated to include a recommendation to enable access to whole-genome sequencing as for surveillance, guidance on strain typing to guide use of subcapsular vaccines, and recognition of the importance of advocacy and awareness campaigns.
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Submitted on : Sunday, February 10, 2019 - 5:27:25 PM
Last modification on : Thursday, April 7, 2022 - 10:10:25 AM

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Ray Borrow, Pedro Alarcón, Josefina Carlos, Dominique A Caugant, Hannah Christensen, et al.. The Global Meningococcal Initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection.. Expert Review of Vaccines, Expert Reviews (formerly Future Drugs), 2017, 16 (4), pp.313-328. ⟨10.1080/14760584.2017.1258308⟩. ⟨pasteur-02013240⟩

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