Delayed Generalized Necrotic Purpuric Rash in a C6-deficient 12-year-old Girl Treated for Group W Meningococcal Disease.

Jean Gaschignard (1) , Nailati Hassani (1) , Carine El Sissy (2) , Stéphane Bonacorsi (1) , Stephane Dauger (1) , Maryline Chomton (1) , Muhamed-Kheir Taha (3) , Michael Lévy (1, 3)

1 AP-HP Hôpital universitaire Robert-Debré [Paris]
2 HEGP - Hôpital Européen Georges Pompidou [APHP]
3 CNR - Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae

We report an unusual case of generalized necrotic purpuric rash that started 48 hours after the initiation of effective third-generation cephalosporin therapy to treat Neisseria meningitidis W infection in a 12-year-old girl. The course was favorable with no shock, and she recovered completely without sequelae. This infection revealed C6 deficiency in our patient.

Keywords: meningococci; Neisseria meningitidis; purpura fulminans; meningitis; C6 deficiency

Domains: Infectious diseases

Jean Gaschignard, Nailati Hassani, Carine El Sissy, Stéphane Bonacorsi, Stephane Dauger, et al.. Delayed Generalized Necrotic Purpuric Rash in a C6-deficient 12-year-old Girl Treated for Group W Meningococcal Disease.. Pediatric Infectious Disease Journal, 2018, 37 (10), pp.1014-1015. ⟨10.1097/INF.0000000000001966⟩. ⟨pasteur-02013221⟩