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The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations.

Reinaldo Acevedo 1 Xilian Bai 2 Ray Borrow 2, * Dominique Caugant 3 Josefina Carlos 4 Mehmet Ceyhan 5 Hannah Christensen 6 Yanet Climent 1 Philippe de Wals 7 Ener Cagri Dinleyici 8 Gabriela Echaniz-Aviles 9 Ahmed Hakawi 10 Hajime Kamiya 11 Andromachi Karachaliou 12 Jay Lucidarme 2 Susan Meiring 13 Konstantin Mironov 14 Marco Sáfadi 15 Zhujun Shao 16 Vinny Smith 17 Robert Steffen 18 Bianca Stenmark 19 Muhamed-Kheir Taha 20 Caroline Trotter 12 Julio A. Vázquez 21 Bingqing Zhu 16
Abstract : Introduction: The 2018 Global Meningococcal Initiative (GMI) meeting focused on evolving invasive meningococcal disease (IMD) epidemiology, surveillance, and protection strategies worldwide, with emphasis on emerging antibiotic resistance and protection of high-risk populations. The GMI is comprised of a multidisciplinary group of scientists and clinicians representing institutions from several continents. Areas covered: Given that the incidence and prevalence of IMD continually varies both geographically and temporally, and surveillance systems differ worldwide, the true burden of IMD remains unknown. Genomic alterations may increase the epidemic potential of meningococcal strains. Vaccination and (to a lesser extent) antimicrobial prophylaxis are the mainstays of IMD prevention. Experiences from across the globe advocate the use of conjugate vaccines, with promising evidence growing for protein vaccines. Multivalent vaccines can broaden protection against IMD. Application of protection strategies to high-risk groups, including individuals with asplenia, complement deficiencies and human immunodeficiency virus, laboratory workers, persons receiving eculizumab, and men who have sex with men, as well as attendees at mass gatherings, may prevent outbreaks. There was, however, evidence that reduced susceptibility to antibiotics was increasing worldwide. Expert commentary: The current GMI global recommendations were reinforced, with several other global initiatives underway to support IMD protection and prevention.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02013210
Contributor : Muhamed-Kheir Taha <>
Submitted on : Sunday, February 10, 2019 - 5:01:01 PM
Last modification on : Monday, July 20, 2020 - 1:06:06 PM

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Reinaldo Acevedo, Xilian Bai, Ray Borrow, Dominique Caugant, Josefina Carlos, et al.. The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations.. Expert Review of Vaccines, Expert Reviews (formerly Future Drugs), 2018, 18 (1), pp.15-30. ⟨10.1080/14760584.2019.1557520⟩. ⟨pasteur-02013210⟩

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