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Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

Hien Bao Dieu Thai 1, 2 Fabienne Levi-Acobas 3 Soo-Young Yum 4 Goo Jang 4 Marcel Hollenstein 3 Dae-Ro Ahn 1, 2, *
* Corresponding author
1 KISTI - Korea Institute of Science and Technology Information
2 UST - University of Science and Technology [Daejeon]
3 Chimie bioorganique des acides nucléiques - Bioorganic chemistry of nucleic acids
4 SNU - Seoul National University [Seoul]
Abstract : We prepared tetrahedral DNAzymes (TDzs) to overcome potential limitations such as insufficient serum stability and poor cellular uptake of single-stranded DNAzymes (ssDzs). TDzs showed enhanced serum stability and higher cellular uptake efficiency compared to those of ssDzs, providing significantly improved intracellular gene-silencing activity to down-regulate the target mRNA level.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02012225
Contributor : Marcel Hollenstein <>
Submitted on : Friday, February 8, 2019 - 3:33:07 PM
Last modification on : Tuesday, June 9, 2020 - 11:46:02 AM

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PASTEUR | CNRS

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Hien Bao Dieu Thai, Fabienne Levi-Acobas, Soo-Young Yum, Goo Jang, Marcel Hollenstein, et al.. Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity. Chemical Communications, Royal Society of Chemistry, 2018, 54 (68), pp.9410-9413. ⟨10.1039/c8cc05721d⟩. ⟨pasteur-02012225⟩

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