Anopheles gambiae pathogen susceptibility: the intersection of genetics, immunity and ecology. - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue Current Opinion in Microbiology Année : 2012

Anopheles gambiae pathogen susceptibility: the intersection of genetics, immunity and ecology.

Résumé

Mosquitoes are the major arthropod vectors of human diseases such as malaria and viral encephalitis. However, each mosquito species does not transmit every pathogen, owing to reasons that include specific evolutionary histories, mosquito immune system structure, and ecology. Even a competent vector species for a pathogen displays a wide range of variation between individuals for pathogen susceptibility, and therefore efficiency of disease transmission. Understanding the molecular and genetic mechanisms that determine heterogeneities in transmission efficiency within a vector species could help elaborate new vector control strategies. This review discusses mechanisms of host-defense in Anopheles gambiae, and sources of genetic and ecological variation in the operation of these protective factors. Comparison is made between functional studies using Plasmodium or fungus, and we call attention to the limitations of generalizing gene phenotypes from experiments done in a single genetically simple colony.
Fichier principal
Vignette du fichier
Mitri-Vernick-2012-Anopheles-gambiae-pathogen.pdf (724.66 Ko) Télécharger le fichier
Loading...

Dates et versions

pasteur-02008330 , version 1 (05-02-2019)

Licence

Paternité

Identifiants

Citer

Christian Mitri, Kenneth D Vernick. Anopheles gambiae pathogen susceptibility: the intersection of genetics, immunity and ecology.. Current Opinion in Microbiology, 2012, 15 (3), pp.285--291. ⟨10.1016/j.mib.2012.04.001⟩. ⟨pasteur-02008330⟩
30 Consultations
332 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More