High proportion of PD-1-expressing CD4 + T cells in adipose tissue constitutes an immunomodulatory microenvironment that may support HIV persistence.

Abderaouf Damouche; Guillaume Pourcher; Valerie Pourcher; Stéphane Benoist; Elodie Busson; Jean-Jacques Lataillade; Mélanie Le Van; Thierry Lazure; Julien Adam; Benoit Favier; Bruno Vaslin; Michaela Müller-Trutwin; Olivier Lambotte; Christine Bourgeois

doi:10.1002/eji.201747060

Journal articles

High proportion of PD-1-expressing CD4 + T cells in adipose tissue constitutes an immunomodulatory microenvironment that may support HIV persistence.

Abderaouf Damouche ¹ Guillaume Pourcher ² Valerie Pourcher ³ Stéphane Benoist ⁴ Elodie Busson ⁵ Jean-Jacques Lataillade ⁵ Mélanie Le Van ¹ Thierry Lazure ⁶ Julien Adam ⁷ Benoit Favier ¹ Bruno Vaslin ¹ Michaela Müller-Trutwin ⁸ Olivier Lambotte ^{1, 9} Christine Bourgeois ^{10, *}

* Corresponding author

1 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes

2 Département de Pathologies digestives [Institut Mutualiste Montsouris]

3 Service des maladies infectieuses [CHU Pitié-Salêtrière]

4 Service de Chirurgie générale et digestive [CHU Le Kremlin-Bicêtre]

5 Hôpital d'instruction des Armées Percy

6 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)

7 PFEP - Plateforme d’évaluation préclinique

AMMICa - Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse

8 HIV, Inflammation et persistance

9 Service de Médecine Interne et Immunologie clinique [AP-HP Hôpital Bicêtre]

10 Régulation de la réponse immune, infection VIH-1 et autoimmunité

Abstract : We and others have demonstrated that adipose tissue is a reservoir for HIV. Evaluation of the mechanisms responsible for viral persistence may lead to ways of reducing these reservoirs. Here, we evaluated the immune characteristics of adipose tissue in HIV-infected patients receiving antiretroviral therapy (ART) and in non-HIV-infected patients. We notably sought to determine whether adipose tissue's intrinsic properties and/or HIV induced alteration of the tissue environment may favour viral persistence. ART-controlled HIV infection was associated with a difference in the CD4/CD8 T-cell ratio and an elevated proportion of Treg cells in subcutaneous adipose tissue. No changes in Th1, Th2 and Th17 cell proportions or activation markers expression on T cell (Ki-67, HLA-DR) could be detected, and the percentage of CD69-expressing resident memory CD4+ T cells was not affected. Overall, our results indicate that adipose-tissue-resident CD4+ T cells are not extensively activated during HIV infection. PD-1 was expressed by a high proportion of tissue-resident memory CD4+ T cells in both HIV-infected patients and non-HIV-infected patients. Our findings suggest that adipose tissue's intrinsic immunomodulatory properties may limit immune activation and thus may strongly contribute to viral persistence.

Keywords : Adipose tissue CD4 T cell Fat HIV HIV persistence PD-1

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Immunology

Life Sciences [q-bio] / Microbiology and Parasitology / Virology

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02007461
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Submitted on : Tuesday, February 5, 2019 - 11:37:58 AM
Last modification on : Thursday, December 10, 2020 - 3:44:22 AM

High proportion of PD-1-expressing CD4 + T cells in adipose tissue constitutes an immunomodulatory microenvironment that may support HIV persistence.

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High proportion of PD-1-expressing CD4 + T cells in adipose tissue constitutes an immunomodulatory microenvironment that may support HIV persistence.

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