Skip to Main content Skip to Navigation
New interface
Journal articles

Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species

Abstract : Horizontal gene transfer has played a role in developing the global public health crisis of antimicrobial resistance (AMR). However, the dynamics of AMR transfer through bacterial populations and its direct impact on human disease is poorly elucidated. Here, we study parallel epidemic emergences of multiple Shigella species, a priority AMR organism, in men who have sex with men to gain insight into AMR emergence and spread. Using genomic epidemiology, we show that repeated horizontal transfer of a single AMR plasmid among Shigella enhanced existing and facilitated new epidemics. These epidemic patterns contrasted with slighter, slower increases in disease caused by organisms with vertically inherited (chromosomally encoded) AMR. This demonstrates that horizontal transfer of AMR directly affects epidemiological outcomes of globally important AMR pathogens and highlights the need for integration of genomic analyses into all areas of AMR research, surveillance and management.
Document type :
Journal articles
Complete list of metadata

Cited literature [44 references]  Display  Hide  Download
Contributor : François-Xavier WEILL Connect in order to contact the contributor
Submitted on : Monday, February 4, 2019 - 12:14:27 PM
Last modification on : Thursday, April 7, 2022 - 10:10:25 AM
Long-term archiving on: : Sunday, May 5, 2019 - 2:46:05 PM


Publication funded by an institution


Distributed under a Creative Commons Attribution 4.0 International License




Kate S Baker, Timothy Dallman, Nigel Field, Tristan Childs, Holly Mitchell, et al.. Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species. Nature Communications, 2018, 9 (1), pp.1462. ⟨10.1038/s41467-018-03949-8⟩. ⟨pasteur-02005961⟩



Record views


Files downloads