Abstract : Graphical Abstract Highlights d EBOV adapted to humans during the West African outbreak d Amino acid substitutions in the EBOV glycoprotein increase human cell tropism d The same glycoprotein amino acid substitutions decrease tropism for bat cells In Brief The Ebola virus acquired amino acid substitutions in its glycoprotein that increased its tropism for human cells during the West African outbreak of 2013-2016.
https://hal-pasteur.archives-ouvertes.fr/pasteur-02003921 Contributor : Anavaj SakuntabhaiConnect in order to contact the contributor Submitted on : Friday, February 22, 2019 - 4:07:35 PM Last modification on : Thursday, April 7, 2022 - 10:10:36 AM Long-term archiving on: : Thursday, May 23, 2019 - 1:56:32 PM
Richard A Urbanowicz, C Patrick Mcclure, Anavaj Sakuntabhai, Amadou Alpha Sall, Gary Kobinger, et al.. Human Adaptation of Ebola Virus during the West African Outbreak. Cell, Elsevier, 2016, 167 (4), pp.1079-1087.e5. ⟨10.1016/j.cell.2016.10.013⟩. ⟨pasteur-02003921⟩