Human Adaptation of Ebola Virus during the West African Outbreak

Richard A Urbanowicz (1) , C Patrick Mcclure (1) , Anavaj Sakuntabhai (2) , Amadou Alpha Sall (3) , Gary Kobinger (4, 5) , Marcel A Müller (6) , Edward C Holmes (7) , Felix Rey (8) , Etienne Simon-Loriere (2) , Jonathan K. Ball (1)

1 UON - University of Nottingham, UK
2 Génétique fonctionnelle des Maladies infectieuses - Functional Genetics of Infectious Diseases
3 Arbovirus et Virus de Fièvres Hémorragiques [Dakar, Sénégal]
4 Public Health Agency of Canada [Winnipeg]
5 University of Manitoba [Winnipeg]
6 University of Bonn Medical Center [Bonn, Germany]
7 The University of Sydney
8 Virologie Structurale - Structural Virology

Graphical Abstract Highlights d EBOV adapted to humans during the West African outbreak d Amino acid substitutions in the EBOV glycoprotein increase human cell tropism d The same glycoprotein amino acid substitutions decrease tropism for bat cells In Brief The Ebola virus acquired amino acid substitutions in its glycoprotein that increased its tropism for human cells during the West African outbreak of 2013-2016.

Keywords: Ebola virus; Makona; adaptation; bat; epistasis; evolution; human; pseudovirus; tropism

Domains: Computer Science [cs]; Bioinformatics [q-bio.QM]; Life Sciences [q-bio]; Quantitative Methods [q-bio.QM]; Life Sciences [q-bio]; Genetics; Human genetics; Life Sciences [q-bio]; Genetics; Populations and Evolution [q-bio.PE]; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology; Life Sciences [q-bio]; Santé publique et épidémiologie

Richard A Urbanowicz, C Patrick Mcclure, Anavaj Sakuntabhai, Amadou Alpha Sall, Gary Kobinger, et al.. Human Adaptation of Ebola Virus during the West African Outbreak. Cell, 2016, 167 (4), pp.1079-1087.e5. ⟨10.1016/j.cell.2016.10.013⟩. ⟨pasteur-02003921⟩