Validation of genotype imputation in Southeast Asian populations and the effect of single nucleotide polymorphism annotation on imputation outcome
Abstract
Background: Imputation involves the inference of untyped single nucleotide polymorphisms (SNPs) in genome-wide association studies. The haplotypic reference of choice for imputation in Southeast Asian populations is unclear. Moreover, the influence of SNP annotation on imputation results has not been examined.
Domains
Computer Science [cs] Bioinformatics [q-bio.QM] Life Sciences [q-bio] Quantitative Methods [q-bio.QM] Life Sciences [q-bio] Genetics Human genetics Life Sciences [q-bio] Genetics Populations and Evolution [q-bio.PE] Life Sciences [q-bio] Microbiology and Parasitology Virology Life Sciences [q-bio] Microbiology and Parasitology Parasitology Life Sciences [q-bio] Santé publique et épidémiologie
Origin : Publication funded by an institution
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