Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients

C. Gustavo de Moraes (1) , Michele Pettito (2) , Juan B Yepez (2) , Anavaj Sakuntabhai (3) , Etienne Simon-Loriere (3) , Mussaret B Zaidi (4, 5) , Matthieu Prot (3) , Claude Ruffié (6) , Susan S Kim (7) , Rando Allikmets (1) , Joseph Terwilliger (1, 8) , Joseph H Lee (1) , Gladys E Maestre (9)

1 CUMC - Columbia University Medical Center
2 Clinica de Ojos de Maracaibo [Vénézuela]
3 Génétique fonctionnelle des Maladies infectieuses - Functional Genetics of Infectious Diseases
4 Hospital General Agustín O’Horán [Merida, Mexico]
5 Michigan State University [East Lansing]
6 Génomique virale et vaccination
7 St Peter's Hospital [Albany, NY, USA]
8 National Institute for Health and Welfare [Helsinki]
9 LUZ - Universidad del Zulia

Introduction. Although the current Zika virus (ZIKV) epidemic is a major public health concern, most reports have focused on congenital ZIKV syndrome, its most devastating manifestation. Severe ocular complications associated with ZIKV infections and possible pathogenetic factors are rarely described. Here, we describe three Venezuelan patients who developed severe ocular manifestations following ZIKV infections. We also analyse their serological response to ZIKV and dengue virus (DENV).

Domaines: Bio-informatique [q-bio.QM]; Bio-Informatique, Biologie Systémique [q-bio.QM]; Génétique humaine; Génétique des populations [q-bio.PE]; Virologie; Parasitologie; Santé publique et épidémiologie

C. Gustavo de Moraes, Michele Pettito, Juan B Yepez, Anavaj Sakuntabhai, Etienne Simon-Loriere, et al.. Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients. JMM Case reports, 2018, 5 (5), ⟨10.1099/jmmcr.0.005145⟩. ⟨pasteur-02003854⟩