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Protein-protein interactions leading to recruitment of the host DNA sliding clamp by the hyperthermophilic Sulfolobus islandicus rod-shaped virus 2

Abstract : Viruses infecting hyperthermophilic archaea typically do not encode DNA polymerases, raising questions regarding their genome replication. Here, using a yeast two-hybrid approach, we have assessed interactions between proteins of Sulfolobus islandicus rod-shaped virus 2 (SIRV2) and the host-encoded proliferating cell nuclear antigen (PCNA), a key DNA replication protein in archaea. Five SIRV2 proteins were found to interact with PCNA, providing insights into the recruitment of host replisome for viral DNA replication.
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Submitted on : Thursday, January 10, 2019 - 4:55:51 PM
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Andrew F. Gardner, Stephen D. Bell, Malcolm F. White, David Prangishvili, Mart Krupovic. Protein-protein interactions leading to recruitment of the host DNA sliding clamp by the hyperthermophilic Sulfolobus islandicus rod-shaped virus 2. Journal of Virology, American Society for Microbiology, 2014, 88 (12), pp.7105--7108. ⟨10.1128/JVI.00636-14⟩. ⟨pasteur-01977399⟩

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