A network perspective on the virus world

Jaime Iranzo (1) , Mart Krupovic (2) , Eugene Koonin (1)

1 NCBI - National Center for Biotechnology Information
2 BMGE - Biologie Moléculaire du Gène chez les Extrêmophiles

Viral evolution is characterized by high rates of horizontal gene transfer and fast sequence divergence. Furthermore, there are no universal genes shared by all viruses. As a result, distant relationships among viruses are better represented by a network than by a tree. Here we discuss 3 network representations of the virus world with decreasing levels of complexity, from a multilayer network that integrates sequence conservation and patterns of gene sharing to a classic genome similarity network. As new tools for network analysis are developed, we expect that novel insights into virus evolution will result from the study of more complex representations of the virus world.

Mots clés: gene sharing network; bipartite network; multilayer network; phylogenomics; viral evolution; viral taxonomy

Domaines: Sciences du Vivant [q-bio]; Virologie; Génomique, Transcriptomique et Protéomique [q-bio.GN]

Jaime Iranzo, Mart Krupovic, Eugene Koonin. A network perspective on the virus world. Communicative and Integrative Biology, 2017, 10 (2), pp.e1296614. ⟨10.1080/19420889.2017.1296614⟩. ⟨pasteur-01977360⟩