MDSCs in infectious diseases: regulation, roles, and readjustment.

Anca Dorhoi (1, 2, 3) , Estibaliz Glaría (4, 5) , Thalía Garcia-Tellez (6) , Natalie E Nieuwenhuizen (3) , Gennadiy Zelinskyy (7) , Benoit Favier (8) , Anurag Singh (9) , Jan Ehrchen (10) , Cornelia Gujer (11) , Christian Münz (11) , Margarida Saraiva (12, 13) , Yahya Sohrabi (10, 14) , Ana E Sousa (15) , Peter Delputte (16) , Michaela Müller-Trutwin (6) , Annabel F Valledor (4, 5)

1 FLI - Friedrich-Loeffler-Institut
2 Universität Greifswald - University of Greifswald
3 MPIIB - Max Planck Institute for Infection Biology
4 University of Barcelona
5 Institute of Biomedicine - IBUB [Barcelona, Spain]
6 HIV, Inflammation et persistance - HIV, Inflammation and Persistence
7 Uniklinik Essen - Universitätsklinikum Essen [Universität Duisburg-Essen]
8 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
9 University of Tübingen
10 WWU - Westfälische Wilhelms-Universität Münster = University of Münster
11 UZH - Universität Zürich [Zürich] = University of Zurich
12 I3S - Instituto de Investigação e Inovação em Saúde
13 IBMC - Instituto de Biologia Molecular e Celular
14 CAS - Czech Academy of Sciences [Prague]
15 ULISBOA - Universidade de Lisboa = University of Lisbon
16 UA - University of Antwerp

Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.

Keywords: Immunosuppression; Infection; Oncogenic viruses; MDSC; Mye-EUNITER; Myeloid regulatory cells

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Immunology; Life Sciences [q-bio]; Immunology; Innate immunity; Life Sciences [q-bio]; Microbiology and Parasitology; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Human health and pathology

Anca Dorhoi, Estibaliz Glaría, Thalía Garcia-Tellez, Natalie E Nieuwenhuizen, Gennadiy Zelinskyy, et al.. MDSCs in infectious diseases: regulation, roles, and readjustment.. Cancer Immunology, Immunotherapy, 2019, 68 (4), pp.673-685. ⟨10.1007/s00262-018-2277-y⟩. ⟨pasteur-01969805⟩