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Improved reference genome of Aedes aegypti informs arbovirus vector control

Benjamin J. Matthews 1, 2, 3 Olga Dudchenko 4, 5 Sara Kingan 6 Sergey Koren 7 Igor Antoshechkin 8 Jacob E. Crawford 9 William Glassford 10 Margaret Herre 1, 3 Seth N. Redmond 11, 12 Noah Rose 13 Gareth D. Weedall 14 Yang Wu 15, 16 Sanjit Batra 4, 5 Carlos Brito-Sierra 17 Steven Buckingham 18 Corey Campbell 19 Saki Chan 20 Eric Cox 21 Benjamin Evans 22 Thanyalak Fansiri 23 Igor Filipović 24 Albin Fontaine 25, 26, 27 Andrea Gloria-Soria 22 Richard Hall 6 Vinita Joardar 21 Andrew K. Jones 28 Raissa Kay 29 Vamsi Kodali 21 Joyce Lee 20 Gareth Lycett 30 Sarah Mitchell 9 Jill Muehling 6 Mickael Murphy 21 Arina Omer 4, 5 Frederick Partridge 18 Paul Peluso 6 Aviva Presser Aiden 4, 5 Vidya Ramasamy 28 Gordana Rašić 24 Sourav Roy 29 Karla Saavedra-Rodriguez 19 Shruti Sharan 17 Atashi Sharma 15 Melissa Laird Smith 6 Joe Turner 31 Allison Weakley 9 Zhilei Zhao 13 Omar Akbari 32 William Black 19 Han Cao 20 Alistair Darby 31 Catherine Hill 17 J Spencer Johnston 33 Terence Murphy 21 Alex Raikhel 29 David Sattelle 18 Igor Sharakhov 15, 34 Bradley White 9 Li Zhao 1 Erez Lieberman Aiden 4, 5, 11 Richard Mann 10 Louis Lambrechts 25 Jeffrey Powell 22 Maria Sharakhova 15, 34 Zhijian Tu 15 Hugh Robertson 35 Carolyn Mcbride 13 Alex Hastie 20 Jonas Korlach 6 Daniel Neafsey 11, 12 Adam Phillippy 7 Leslie Vosshall 1, 3, 36
1 Rockefeller University [New York]
2 HHMI - Howard Hughes Medical Institute [New York]
3 Kavli Neural Systems Institute
4 BCM - Baylor College of Medicine
5 Rice University [Houston]
6 Pacific Biosciences [Menlo Park]
7 NHGRI - National Human Genome Research Institute
8 CALTECH - California Institute of Technology
9 Verily Life Sciences Inc
10 Columbia University [New York]
11 BROAD INSTITUTE - Broad Institute of MIT and Harvard
12 Harvard T.H. Chan School of Public Health
13 Princeton University
14 LJMU - Liverpool John Moores University
15 Virginia Tech [Blacksburg]
16 Southern Medical University [Guangzhou]
17 Purdue University [West Lafayette]
18 UCL - University College of London [London]
19 CSU - Colorado State University [Fort Collins]
20 Bionano Genomics Inc
21 NCBI - National Center for Biotechnology Information
22 Yale University [New Haven]
23 AFRIMS - Armed Forces Research Institute of Medical Sciences [Bangkok]
24 QIMR Berghofer Medical Research Institute
25 IVI - Interactions Virus-Insectes - Insect-Virus Interactions
26 IRBA - Institut de Recherche Biomédicale des Armées [Antenne Marseille]
27 VITROME - Vecteurs - Infections tropicales et méditerranéennes
28 Oxford Brookes University
29 UCR - University of California [Riverside]
30 LSTM - Liverpool School of Tropical Medicine
31 University of Liverpool
32 UC San Diego - University of California [San Diego]
33 Texas A&M University [College Station]
34 Tomsk State University [Tomsk]
35 UIC - University of Illinois [Chicago]
36 Howard Hughes Medical Institute [New York]
Abstract : Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.
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Benjamin J. Matthews, Olga Dudchenko, Sara Kingan, Sergey Koren, Igor Antoshechkin, et al.. Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature, Nature Publishing Group, 2018, 563 (7732), pp.501-507. ⟨10.1038/s41586-018-0692-z⟩. ⟨pasteur-01969223⟩

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