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Emna Harigua-Souiai, Yosser Zina Abdelkrim, Imen Bassoumi-Jamoussi, Ons Zakraoui, Guillaume Bouvier, Khadija Essafi-Benkhadir, Josette Banroques, Nathan Desdouits, Hélène Munier-Lehmann, Mourad Barhoumi, N. Kyle Tanner, Michael Nilges, Arnaud Blondel, Ikram Guizani
Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A
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(33)Tj
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3.5262 0 Td
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0 w
7.4999 0 0 6.6659 502.9795 347.8677 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
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(2+)Tj
ET
Q
q
1 j
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0 w
10 0 0 10 510.9165 343.3889 cm
BT
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(37)Tj
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(41)Tj
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(the)Tj
1.4683 0 Td
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2.0976 0 Td
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3.515 0 Td
(both)Tj
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3.1351 0 Td
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(37)Tj
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(,)Tj
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1.7405 0 Td
(42)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(44)Tj
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(])Tj
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1.0261 0 Td
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(linker)Tj
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(flexibility.)Tj
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1.0261 0 Td
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2.8346 0 Td
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([)Tj
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(45)Tj
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(,)Tj
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1.7348 0 Td
(46)Tj
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(])Tj
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(the)Tj
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(ADP)Tj
2.1996 0 Td
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(inorganic)Tj
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3.4072 0 Td
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(])Tj
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([)Tj
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(9)Tj
0 g
(])Tj
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(RNA)Tj
-34.0267 -1.2983 Td
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(the)Tj
1.4684 0 Td
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(protein.)Tj
3.3789 0 Td
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1.61 0 Td
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(\(higher)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 414.1984 185.7259 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(m)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F11 1 Tf
1 TL
-0.004 Tc
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BT
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1 TL
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Q
q
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1 J
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BT
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1 TL
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2.3697 0 Td
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2.1883 0 Td
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3.0273 0 Td
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0.8618 0 Td
(also)Tj
1.7631 0 Td
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1.542 0 Td
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ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 288.3401 152.844 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
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(2+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 296.2204 148.422 cm
BT
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1 TL
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3.0897 0 Td
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-34.6674 -1.3039 Td
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(the)Tj
1.4683 0 Td
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4.0025 0 Td
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1.7744 0 Td
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3.1294 0 Td
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-34.5597 -1.2983 Td
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1.4739 0 Td
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7.8349 0 Td
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Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 183.2882 23.6976 re
W* n
q
183.2315 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 320.3716 745.7952 cm
BT
/F0 1 Tf
1 TL
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1.3111 0 Td
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(novel)Tj
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(a)Tj
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ET
Q
q
1 j
1 J
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576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
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163.5591 34.9228 m
317.7071 34.9228 l
h
f*
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7.9999 0 0 7.9999 36 36 cm
BT
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1 TL
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2.8559 0 Td
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(s)Tj
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(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8197 0 Td
(1/journal.pn)Tj
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(td.00061)Tj
3.8197 0 Td
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0 g
2.0905 0 Td
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3.7205 0 Td
(18,)Tj
1.5804 0 Td
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23.6269 0 Td
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