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Enhancing studies of the connectome in autism using the autism brain imaging data exchange II

Adriana Di Martino 1 David O’connor 2, 3 Bosi Chen 1 Kaat Alaerts 4 Jeffrey Anderson 5 Michal Assaf 6, 7 Joshua Balsters 8 Leslie Baxter 9 Anita Beggiato 10, 11 Sylvie Bernaerts 4 Laura Blanken 12 Susan Bookheimer 13 B. Blair Braden 9, 14 Lisa Byrge 15 F. Xavier Castellanos 1, 2 Mirella Dapretto 13 Richard Delorme 10, 11 Damien Fair 16 Inna Fishman 17 Jacqueline Fitzgerald 18, 19 Louise Gallagher 18, 19 R. Joanne Jao Keehn 17 Daniel Kennedy 15 Janet Lainhart 5, 20 Beatriz Luna 21 Stewart Mostofsky 22, 23 Ralph-Axel Müller 17 Mary Nebel 22, 23 Joel Nigg 16 Kirsten O’hearn 21 Marjorie Solomon 24 Roberto Toro 11 Chandan Vaidya 25, 26 Nicole Wenderoth 8 Tonya White 12 R. Cameron Craddock 2, 3 Catherine Lord 27 Bennett Leventhal 28 Michael Milham 2, 3
Abstract : The second iteration of the Autism Brain Imaging Data Exchange (ABIDE II) aims to enhance the scope of brain connectomics research in Autism Spectrum Disorder (ASD). Consistent with the initial ABIDE effort (ABIDE I), that released 1112 datasets in 2012, this new multisite open-data resource is an aggregate of resting state functional magnetic resonance imaging (MRI) and corresponding structural MRI and phenotypic datasets. ABIDE II includes datasets from an additional 487 individuals with ASD and 557 controls previously collected across 16 international institutions. The combination of ABIDE I and ABIDE II provides investigators with 2156 unique cross-sectional datasets allowing selection of samples for discovery and/or replication. This sample size can also facilitate the identification of neurobiological subgroups, as well as preliminary examinations of sex differences in ASD. Additionally, ABIDE II includes a range of psychiatric variables to inform our understanding of the neural correlates of co-occurring psychopathology; 284 diffusion imaging datasets are also included. It is anticipated that these enhancements will contribute to unraveling key sources of ASD heterogeneity.
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Adriana Di Martino, David O’connor, Bosi Chen, Kaat Alaerts, Jeffrey Anderson, et al.. Enhancing studies of the connectome in autism using the autism brain imaging data exchange II. Scientific Data , Nature Publishing Group, 2017, 4, pp.170010. ⟨10.1038/sdata.2017.10⟩. ⟨pasteur-01967214⟩

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