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Journal articles
Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents
S Desrivières
1, *
A Lourdusamy
1
C. Tao
2
R Toro
3
T Jia
1
E Loth
1
L Medina
1
A Kepa
1
A Fernandes
1
B Ruggeri
1
F. Carvalho
1
G Cocks
1
T. Banaschewski
4, 5
G Barker
1
A Bokde
6
C Büchel
7
P Conrod
1, 8, 9
H Flor
10, 11
A. Heinz
12
J Gallinat
12
H Garavan
6, 13
P Gowland
13
R Brühl
14
C Lawrence
15
K. Mann
4
M Martinot
16, 17
F Nees
4
M. Lathrop
18
J-B Poline
19
M Rietschel
4
P Thompson
20
M Fauth-Bühler
4
M Smolka
21
Z Pausova
22
T Paus
15, 22, 23
J Feng
2, 24
G. Schumann
1
*
Corresponding author
S Desrivières 1
Mail :
Correspondent author
A Lourdusamy 1
Author
C. Tao 2
Author
R Toro 3
Mail :
Author IdHAL : robertotoro ORCID : https://orcid.org/0000-0002-6671-858X
G. Schumann 1
Author
1
Institute of Psychiatry, Psychology & Neuroscience, King's College London (Institute of Psychiatry, Psychology & Neuroscience King's College London 16 De Crespigny Park London SE5 8AF - United Kingdom)
- King‘s College London (Strand Campus, London WC2R 2LS - United Kingdom)
2
Fudan University [Shanghai] (Shanghai, Yangpu - China)
3
GHFC (UMR_3571 / U-Pasteur_1) - Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (C3BI / Département de Neuroscience - 25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- UPD7 - Université Paris Diderot - Paris 7 : U-Pasteur_1 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR_3571 (France)
5
University of Heidelberg, Medical Faculty (Germany)
6
Trinity College Dublin (College Green, Dublin 2, Ireland - Ireland)
7
UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (Martinistraße 52
20251 Hamburg - Germany)
8
CHU Sainte Justine [Montréal] (3175, Chemin de la Côte-Sainte-Catherine, Montréal H3T 1C5, Québec - Canada)
9
Université de Montréal [Montréal] (C.P. 6128, succursale Centre-ville Montréal (Québec) H3C 3J7 - Canada)
10
Medical Faculty [Mannheim] (Germany)
11
Universität Heidelberg [Heidelberg] ( Seminarstraße 2, 69117 Heidelberg - Germany)
12
Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin (Charitéplatz, 10117 Berlin - Germany)
13
University of Vermont [Burlington] (Burlington, VT 05405 - United States)
14
PTB - Physikalisch-Technische Bundesanstalt [Berlin] (Abbestrasse 2-12, D-10587 Berlin - Germany)
15
UON - University of Nottingham, UK (University of Nottingham
University Park
Nottingham
NG7 2RD - United Kingdom)
16
U1000 - Neuroimagerie en psychiatrie (CEA - Service Hospitalier Frédéric Joliot 4, place du Général Leclerc 91401 Orsay Cedex - France)
- UP11 - Université Paris-Sud - Paris 11 : UMR_S 1000 (Bâtiment 300 - 91405 Orsay cedex - France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : UMR_S 1000 (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- UPD5 - Université Paris Descartes - Paris 5 : UMR_S 1000 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1000 (101, rue de Tolbiac, 75013 Paris - France)
17
Maison de Solenn [CHU Cochin] (Maison des adolescents- Cochin-Paris, 97 Bd de Port Royal, 75679 Paris Cedex 14 - France)
- APHP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Cochin [AP-HP] (27 Rue du Faubourg Saint-Jacques 75014 Paris - France)
18
CNG - Centre National de Génotypage (Centre National de Génotypage 2 rue Gaston Crémieux CP5721 91057 EVRY Cedex - France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DSV/IG (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
19
NEUROSPIN - Service NEUROSPIN (France)
- DRF (CEA) - Direction de Recherche Fondamentale (CEA) : DRF/JOLIOT (Direction de Recherche Fondamentale
Fundamental Research Division
CEA Saclay
91191 Gif-sur-Yvette
- France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- Université Paris-Saclay (Espace Technologique, Bat. Discovery - RD 128 - 2e ét., 91190 Saint-Aubin - France)
20
School of Medicine [Los Angeles] (10833 Le Conte Ave, Los Angeles, CA 90095 - United States)
- UCLA - University of California [Los Angeles] ( Los Angeles, Californie 90095 - United States)
- University of California (United States)
21
TUD - Technische Universität Dresden (TU Dresden 01062 Dresden - Germany)
22
University of Toronto (27 King's College Circle, Toronto M5S 1A1 - Canada)
23
McGill University (845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4 - Canada)
24
University of Warwick [Coventry] (Coventry CV4 7AL - United Kingdom)
Abstract : Despite the recognition that cortical thickness is heritable and correlates with intellectual ability in children and adolescents, the genes contributing to individual differences in these traits remain unknown. We conducted a large-scale association study in 1583 adolescents to identify genes affecting cortical thickness. Single-nucleotide polymorphisms (SNPs; n = 54 837) within genes whose expression changed between stages of growth and differentiation of a human neural stem cell line were selected for association analyses with average cortical thickness. We identified a variant, rs7171755, associating with thinner cortex in the left hemisphere (P = 1.12 × 10 −7), particularly in the frontal and temporal lobes. Localized effects of this SNP on cortical thickness differently affected verbal and nonverbal intellectual abilities. The rs7171755 polymorphism acted in cis to affect expression in the human brain of the synaptic cell adhesion glycoprotein-encoding gene NPTN. We also found that cortical thickness and NPTN expression were on average higher in the right hemisphere, suggesting that asymmetric NPTN expression may render the left hemisphere more sensitive to the effects of NPTN mutations, accounting for the lateralized effect of rs7171755 found in our study. Altogether, our findings support a potential role for regional synaptic dysfunctions in forms of intellectual deficits.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01967174
Contributor : Roberto Toro <>
Submitted on : Sunday, December 30, 2018 - 6:15:13 PM
Last modification on : Saturday, April 11, 2020 - 1:58:03 AM
Document(s) archivé(s) le : Sunday, March 31, 2019 - 12:59:08 PM
Contributor : Roberto Toro <>
Submitted on : Sunday, December 30, 2018 - 6:15:13 PM
Last modification on : Saturday, April 11, 2020 - 1:58:03 AM
Document(s) archivé(s) le : Sunday, March 31, 2019 - 12:59:08 PM
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desrivires-schumann2014.pdf
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Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License
Identifiers
- HAL Id : pasteur-01967174, version 1
- DOI : 10.1038/mp.2013.197
- PUBMED : 24514566
- PUBMEDCENTRAL : PMC4051592
Collections
PASTEUR | CNRS | CEA | UNIV-PARIS5 | JACOB | JOLIOT | CEA-DRF | NEUROSPIN | USPC | UNIV-PARIS-SACLAY | UNIV-PARIS7 | CEA-UPSAY | UP-SCIENCES
Citation
S Desrivières, A Lourdusamy, C. Tao, R Toro, T Jia, et al.. Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents. Molecular Psychiatry, Nature Publishing Group, 2015, 20 (2), pp.263-274. ⟨10.1038/mp.2013.197⟩. ⟨pasteur-01967174⟩
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