A. Angold, E. J. Costello, and A. Erkanli, Comorbidity, Journal of Child Psychology and Psychiatry and Allied Disciplines, vol.40, pp.57-87, 1999.

H. Anckarsäter, S. Lundström, L. Kollberg, N. Kerekes, C. Palm et al., The twin and adolescent twin study in Sweden (CATSS), Twin Research and Human Genetics, vol.14, pp.495-508, 2011.

S. Bölte, M. Holtmann, F. Poustka, A. Scheurich, and L. Schmidt, Gestalt perception and local-global processing in high-functioning autism, Journal of Autism and Developmental Disorder, vol.37, pp.1493-14504, 2007.

F. X. Castellanos, W. S. Sharp, R. F. Gottesman, D. K. Greenstein, J. N. Giedd et al., Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder, American Journal of Psychiatry, vol.160, pp.1693-1696, 2003.

E. Caylak, Biochemical and genetic analyses of child attention deficit/hyperactivity disorder, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol.159, pp.613-627, 2012.

Z. Chang, P. Lichtenstein, P. J. Asherson, and H. Larsson, Developmental twin study of attention problems: High heritabilities throughout development, JAMA Psychiatry, vol.70, pp.311-318, 2013.

A. Chauhan and V. Chauhan, Oxidative stress in autism, Pathophysiology, vol.13, pp.171-181, 2006.

K. C. Christian, H. Song, and G. Ming, Application of reprogrammed patient cells to investigate the etiology of neurological and psychiatric disorders, Frontiers in Biology, vol.7, pp.179-188, 2012.

J. N. Constantino and R. D. Todd, Autistic traits in the general population-A twin study, Archives of General Psychiatry, vol.60, pp.524-530, 2003.

E. Courchesne, K. Campbell, and S. Solso, Brain growth across the life span in autism: Age-specific changes in anatomical pathology, Brain Research, vol.1380, pp.138-145, 2011.

E. Courchesne and K. Pierce, Why the frontal cortex in autism might be talking only to itself: Local over-connectivity but long-distance disconnection, Current Opinion in Neurobiology, vol.15, pp.225-230, 2005.

M. De-angelis, M. Piccolo, L. Vannini, S. Siragusa, A. De-giacomo et al., , 2013.

, Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified, PLoS One, vol.8, p.76993

T. J. Devito, D. J. Drost, R. W. Neufeld, N. Rajakumar, W. Pavlovsky et al., Evidence for cortical dysfunction in autism: A proton magnetic resonance spectroscopic imaging study, Biological Psychiatry, vol.61, pp.465-473, 2007.

B. Devlin and S. W. Scherer, Genetic architecture in autism spectrum disorder, Current Opinion in Genetics & Development, vol.22, pp.229-237, 2012.

S. Durston, Converging methods in studying attention-deficit/hyperactivity disorder: What can we learn from neuroimaging and genetics? Development and Psychopathology, vol.20, pp.1133-1143, 2008.

I. Dziobek and S. Bölte, Neuropsychological models of autism spectrum disorders-behavioral evidence and functional imaging, vol.39, pp.79-90, 2011.

C. Ecker, W. Spooren, and D. G. Murphy, Translational approaches to the biology of autism: False dawn or a new era, Molecular Psychiatry, vol.18, pp.435-442, 2013.

A. Falk, P. Koch, J. Kesavan, Y. Takashima, J. Ladewig et al., Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons, PLoS One, vol.7, p.29597, 2012.

E. Fombonne, Epidemiology of pervasive developmental disorder, Pediatric Research, vol.65, pp.591-598, 2009.

T. E. Froehlich, J. S. Anixt, I. M. Loe, V. Chirdkiatgumchai, L. Kuan et al., Update on Environmental Risk Factors for Attention-Deficit/Hyperactivity Disorder, Current Psychiatry Reports, vol.13, pp.333-344, 2011.

T. E. Froehlich, B. P. Lamphear, J. N. Epstein, W. J. Barbaresi, S. K. Katusic et al., Prevalence, recognition, and treatment of attention-deficit/hyperactivity, 2007.

. Sven-b-¨-olte, disorder in a national sample of US children, Archives of Pediatrics & Adolescent Medicine, vol.161, pp.857-864

M. E. Geraghty, J. Bates-wall, K. Ratliff-schaub, and A. E. Lane, Nutritional interventions and therapies in autism: A spectrum of what we know: Part 2. Infant, Child, & Adolescent Nutrition, vol.2, pp.120-133, 2010.

D. H. Geschwind and P. Lewitt, Autism spectrum disorders: developmental disconnection syndromes, Current Opinion in Neurobiology, vol.17, pp.103-111, 2007.
DOI : 10.1016/j.conb.2007.01.009

D. Grafodatskaya, B. Chung, P. Szatmari, and R. Weksberg, Autism spectrum disorders and epigenetics, Journal of the American Academy of Child and Adolescent Psychiatry, vol.49, pp.794-809, 2010.

M. M. Groen-blokhuis, C. M. Middeldorp, C. E. Van-beijsterveldt, and D. I. Boomsma, Evidence for a causal association of low birth weight and attention problems, Journal of the American Academy of Child & Adolescent Psychiatry, vol.50, pp.1247-1254, 2011.

J. Hallmayer, E. J. Glasson, C. Bower, B. Petterson, L. Croen et al., On the twin risk in autism, American Journal of Human Genetics, vol.71, pp.941-946, 2002.

U. Hannelius, L. Gherman, V. V. Makela, A. Lindstedt, M. Zucchelli et al., , 2007.

, Large-scale zygosity testing using single nucleotide polymorphisms, Twin Research and Human Genetics, vol.10, pp.604-625

F. Happé and A. Ronald, Fractionable Autism Triad': A review of evidence from behavioural, genetic, cognitive and neural research, Neuropsychology Review, vol.18, pp.287-304, 2008.

P. Heiser, S. Friedel, A. Dempfle, K. Konrad, J. Smidt et al., Molecular genetic aspects of attention-deficit/hyperactivity disorder, Neuroscience and Biobehavioral Reviews, vol.28, pp.625-641, 2004.

M. R. Herbert, Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders, Current Opinion in Neurology, vol.23, pp.103-110, 2010.

R. A. Hoekstra, M. Bartels, C. J. Verweij, and D. I. Boomsma, Heritability of autistic traits in the general population, Archives of Pediatrics & Adolescent Medicine, vol.161, pp.372-377, 2007.

M. Hölttä, H. Zetterberg, E. Mirgorodskaya, N. Mattsson, K. Blennow et al., Peptidome analysis of cerebrospinal fluid by LC-MALDI MS, PLoS One, vol.7, p.42555, 2012.

V. W. Hu, B. C. Frank, S. Heine, N. H. Lee, and J. Quackenbush, Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes, BMC Genomics, vol.7, p.118, 2006.

S. Idring, D. Rai, H. Dal, C. Dalman, H. Sturm et al., Autism spectrum disorders in the Stockholm Youth Cohort: Design, prevalence and validity, PLoS One, vol.7, p.41280, 2012.

B. Jagatha, M. S. Divya, R. Sanalkumar, C. L. Indulekha, S. Vidyanand et al.,

J. James, In vitro differentiation of retinal ganglion-like cells from embryonic stem cell derived neural progenitors, Biochemical and Biophysical Research Communications, vol.380, pp.230-235, 2009.

C. R. Jung, Y. T. Lin, and B. F. Hwang, Air pollution and newly diagnostic autism spectrum disorders: A populationbased cohort study in Taiwan, PLoS One, vol.25, p.75510, 2013.

W. R. Kates, C. P. Burnette, S. Eliez, L. A. Strunge, D. Kaplan et al., Neuroanatomic variation in monozygotic twin pairs discordant for the narrow phenotype for autism, American Journal of Psychiatry, vol.161, pp.539-546, 2004.

W. R. Kates, I. Ikuta, and C. P. Burnette, Gyrification patterns in monozygotic twin pairs varying in discordance for autism, Autism Research, vol.2, pp.267-278, 2009.

W. R. Kates, S. H. Mostofsky, A. W. Zimmerman, M. M. Mazzocco, R. Landa et al., Neuroanatomical and neurocognitive differences in a pair of monozygous twins discordant for strictly defined autism, Annals of Neurology, vol.43, pp.782-791, 1998.

Y. S. Kim, B. L. Leventhal, Y. J. Koh, E. Fombonne, E. Laska et al.,

R. R. Grinker, Prevalence of autism spectrum disorders in a total population sample, American Journal of Psychiatry, vol.168, pp.904-912, 2011.

K. Konrad and S. B. Eickhoff, Is the ADHD brain wired differently? A review on structural and functional connectivity in attention deficit hyperactivity disorder, Human Brain Mapping, vol.31, pp.904-916, 2010.

T. V. Kral, W. T. Eriksen, M. C. Souders, and J. A. Pinto-martin, Eating behaviors, diet quality, and gastrointestinal symptoms in children with autism spectrum disorders: A brief review, Journal of Pediatric Nursing, vol.28, pp.548-556, 2013.

A. C. Kroksveen, J. A. Opsahl, T. T. Aye, R. J. Ulvik, and F. S. Berven, Proteomics of human cerebrospinal fluid: Discovery and verification of biomarker candidates in neurodegenerative diseases using quantitative proteomics, Journal of Proteomics, vol.74, pp.371-5388, 2011.

H. Larsson, H. Anckarsäter, M. Råstam, Z. Chang, and P. Lichtenstein, Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: A quantitative genetic study of 8,500 twin pairs, Journal of Child Psychology and Psychiatry, vol.53, pp.73-580, 2012.

H. Lehn, E. M. Derks, J. J. Hudziak, P. Heutink, T. C. Van-beijsterveldt et al., Attention problems and attention-deficit/hyperactivity disorder in discordant and concordant monozygotic twins: Evidence of environmental mediators, Journal of the American Academy of Child and Adolescent Psychiatry, vol.46, pp.83-91, 2007.

S. E. Levy, D. S. Mandell, and R. T. Schultz, Autism. The Lancet, vol.9701, pp.1627-1638, 2009.

P. Lichtenstein, E. Carlström, M. Råstam, C. Gillberg, and H. Anckarsäter, The genetics of autism spectrum disorder and related neuropsychiatric disorders in childhood, The American Journal of Psychiatry, vol.167, pp.1357-1363, 2010.

S. Lundström, Z. Chang, M. Råstam, C. Gillberg, H. Larsson et al., Autism spectrum disorders and autistic like traits similar etiology in the extreme end and the normal variation, Archives of General Psychiatry, vol.69, pp.46-52, 2012.

N. Martin, D. Boomsma, and G. Machin, A twinpronged attack on complex traits, Nature Genetics, vol.17, pp.387-392, 1997.

E. A. Mayer, Gut feelings: The emerging biology of gut-brain communication, Nature Reviews Neuroscience, vol.12, pp.453-466, 2012.

S. R. Mitchell, A. L. Reiss, D. H. Tatusko, I. Ikuta, D. B. Kazmerski et al., Neuroanatomic alterations and social and communication deficits in monozygotic twins discordant for autism disorder, The American Journal of Psychiatry, vol.166, pp.917-925, 2009.

A. Moreno-de-luca, S. M. Myers, T. D. Challman, D. Morenode-luca, D. W. Evans et al., Developmental brain dysfunction: Revival and expansion of old concepts based on new genetic evidence, The Lancet Neurology, vol.12, pp.406-414, 2013.

S. Normand, D. B. Flora, M. E. Toplak, and R. Tannock, Evidence for a general ADHD factor from a longitudinal general school population study, Journal of Abnormal Child Psychology, vol.40, pp.555-567, 2012.
DOI : 10.1007/s10802-011-9584-5

C. A. Pardo and C. G. Eberhart, The neurobiology of autism, Brain Pathology, vol.17, pp.434-447, 2007.

I. H. Park, N. Arora, H. Huo, N. Maherali, T. Ahfeldt et al., Diseasespecific induced pluripotent stem cells, Cell, vol.134, pp.877-886, 2008.

E. T. Parner, S. Baron-cohen, M. B. Lauritsen, M. Jorgensen, L. A. Schieve et al., Parental age and autism spectrum disorders, Annals of Epidemiology, vol.22, pp.143-150, 2012.

S. P. Pasca, T. Portmann, I. Voineagu, M. Yazawa, A. Shcheglovitov et al., Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome, Nature Medicine, vol.17, pp.1657-1662, 2011.

P. Pastor and C. Reuben, Calculations from the National Health Interview Survey, 2001.

J. G. Pearsall-jones, J. P. Piek, N. C. Martin, D. Rigoli, F. Levy et al., A monozygotic twin design to investigate etiological factors for DCD and ADHD, Journal of Pediatric Neurology, vol.6, pp.209-219, 2008.

J. G. Pearsall-jones, J. P. Piek, D. Rigoli, N. C. Martin, and F. Levy, An investigation into etiological pathways of DCD and ADHD using a monozygotic twin design, Twin Research and Human Genetics, vol.12, pp.381-391, 2009.

R. H. Perlis, Translating biomarkers to clinical practice, Molecular Psychiatry, vol.16, pp.1076-1087, 2011.
DOI : 10.1038/mp.2011.63
URL : http://europepmc.org/articles/pmc3752672?pdf=render

A. M. Persico and V. Napolioni, Autism genetics. Behavioural Brain Research, vol.251, pp.95-112, 2013.
DOI : 10.1016/j.bbr.2013.06.012

G. Polanczyk, M. S. De-lima, B. L. Horta, J. Biederman, and L. A. Rohde, The worldwide prevalence of ADHD: A systematic review and metaregression analysis, American Journal of Psychiatry, vol.164, pp.942-948, 2007.

D. A. Regier, W. E. Narrow, E. A. Kuhl, and D. J. Kupfer, The conceptual development of DSM-V, American Journal of Psychiatry, vol.166, pp.645-650, 2009.

K. L. Reichelt and A. M. Knivsberg, The possibility and probability of a gut-to-brain connection in autism, Annals of Clinical Psychiatry, vol.21, pp.205-211, 2009.

A. M. Reiersen, J. N. Constantino, M. Grimmer, N. G. Martin, and R. D. Todd, Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins, Twin Research and Human Genetics, vol.11, pp.579-585, 2008.
DOI : 10.1375/twin.11.6.579
URL : http://europepmc.org/articles/pmc2840992?pdf=render

E. Robinson, K. C. Koenen, M. C. Mccormick, K. Munir, V. Hallett et al., Evidence that autistic traits show the same etiology in the general population and at the quantitative extremes (5%, 2.5% and 1%), Archives of General Psychiatry, vol.68, pp.1113-1121, 2011.

A. Ronald, F. Happé, K. Dworzynski, P. Bolton, and R. Plomin, Exploring the relationship between prenatal and neonatal complications and later autistic-like features in a representative community sample of twins, Child Development, vol.81, pp.166-182, 2010.

A. Ronald, E. Simonoff, J. Kuntsi, P. Asherson, and R. Plomin, Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample, Journal of Child Psychology and Psychiatry, vol.49, pp.535-542, 2008.

A. Ronald and R. A. Hoekstra, Autism spectrum disorders and autistic traits: A decade of new twin studies, American Journal of Medical Genetetics Part B: Neuropsychiatric Genetics, vol.156, pp.255-274, 2011.

A. Ronald, H. Larsson, H. Anckarsäter, and P. Lichtenstein, A twin study of autism symptoms in Sweden. Molecular Psychiatry, vol.16, pp.1039-1047, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00557775

M. Rutter, Incidence of autism spectrum disorders: Changes over time and their meaning, Acta Paediatrica, vol.94, pp.2-15, 2005.

A. Senju, Atypical development of spontaneous social cognition in autism spectrum disorders, Brain and Development, vol.35, pp.96-101, 2013.

W. S. Sharp, R. F. Gottesman, D. K. Greenstein, C. L. Ebens, J. L. Rapoport et al., Monozygotic twins discordant for attention-deficit/hyperactivity disorder: Ascertainment and clinical characteristics, Journal of the American Academy of Child and Adolescent Psychiatry, vol.42, pp.93-97, 2003.

M. Shokouhi, J. H. Williams, G. D. Waiter, and B. Condon, Changes in the sulcal size associated with autism spectrum disorder revealed by sulcal morphometry, Austism Research, vol.5, pp.245-252, 2012.

E. Simonoff, A. Pickles, T. Charman, S. Chandler, T. Loucas et al., Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample, Journal of the American Academy of Child and Adolescent Psychiatry, vol.47, pp.921-929, 2008.

A. K. Smith, E. Mick, and S. V. Faraone, Advances in genetic studies of attention-deficit/hyperactivity disorder, Current Psychiatry Reports, vol.11, pp.143-148, 2009.

E. Sonuga-barke, P. Bitsakou, and M. Thompson, Beyond the dual pathway model: Evidence for the dissociation of timing, inhibitory, and delay-related impairments in attention-deficit/hyperactivity disorder, Journal of the American Academy of Child and Adolescent Psychiatry, vol.49, pp.345-355, 2010.

, TWIN RESEARCH AND HUMAN GENETICS

. Sven-b-¨-olte,

O. Sporns, G. Tononi, and R. Kötter, The human connectome: A structural description of the human brain, PLoS Computational Biology, vol.1, p.42, 2005.

M. J. Taylor, T. Charman, E. B. Robinson, R. Plomin, F. Happe et al., Developmental associations between traits of autism spectrum disorder and attention-deficit/hyperactivity disorder: A genetically-informative, longitudinal twin study, Psychological Medicine, vol.43, pp.1735-1746, 2013.

G. Tripp and J. Wickens, Neurobiology of ADHD, vol.57, pp.579-589, 2009.

D. Van't-ent, C. E. Van-beijsterveldt, E. M. Derks, J. J. Hudziak, D. J. Veltman et al., Neuroimaging of response interference in twins concordant or discordant for attention and hyperactivity symptoms, Neuroscience, vol.164, pp.16-29, 2009.

M. E. Vissers, M. X. Cohen, and H. M. Geurts, Brain connectivity and high functioning autism: A promising path of research that needs refined models methodological convergence and stronger behavioral links, Neuroscience and Biobehavioral Reviews, vol.36, pp.604-625, 2012.

S. J. Wadsworth, J. C. Defries, R. K. Olson, and E. G. Willcut, Colorado longitudinal twin study of reading disability, Annals of Dyslexia, vol.57, pp.139-160, 2007.

A. Wazana, M. Bresnahan, and J. Kline, Journal of the American Academy of Child and Adolescent Psychiatry, vol.46, pp.721-730, 2007.

C. C. Wong, E. M. Meaburn, A. Ronald, T. S. Price, A. R. Jeffries et al.,

, Methylomic analysis of monozygotic twins discordant for autism spectrum disorder (ASD) and related behavioural traits, Molecular Psychiatry

A. C. Wood and M. C. Neale, Twin studies and their implications for molecular genetic studies: Endophenotypes integrate quantitative and molecular genetics in ADHD research, Journal of the American Academy of Child and Adolescent Psychiatry, vol.49, pp.874-883, 2010.