Journal articles

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Paul M. Thompson ¹ Jason J Stein ² Sarah Medland ³ Derrek D Hibar ⁴ Alejandro Arias Vasquez Miguel E Renteria Roberto Toro ⁵ Neda M Jahanshad ² Gunter Schumann ⁶ Barbara Franke ⁷ Margaret Wright ⁸ Nicholas M Martin ⁹ Ingrid Agartz ¹⁰ Martin Alda ¹¹ Saud Alhusaini ¹² Laura Almasy ¹³ Jorge Almeida ¹⁴ Kathryn Alpert Nancy C Andreasen Ole A. Andreassen ¹⁰ Liana G Apostolova Katja Appel ¹⁵ Nicola J Armstrong Benjamin Aribisala Mark Bastin ¹⁶ Michael Bauer ¹⁷ Carrie D Bearden ⁷ Ørjan Bergmann Elisabeth Binder ¹⁸ John Blangero ¹⁹ Henry J Bockholt Erlend Bøen Catherine Bois Dorret Boomsma ³ Tom Booth Ian J Bowman Janita Bralten ²⁰ Rachel D Brouwer ²¹ Han G. Brunner ²² David G Brohawn Randy L Buckner ²³ Jan Buitelaar ²⁴ Kazima M Bulayeva ²⁵ Juan R Bustillo Vince D Calhoun Dara D Cannon ²⁶ Rita Cantor ²⁷ Melanie A Carless Xavier Caseras Gianpiero L Cavalleri M. Mallar Chakravarty ²⁸ Kiki D Chang Christopher Ching ²⁹ Andrea Christoforou Sven Cichon ²⁷ Vincent P Clark Patricia Conrod ⁶ Giovanni Coppola ³⁰ Benedicto Crespo-Facorro ³¹ Joanne E Curran Michael Czisch ³² Ian Deary ³ Eco de Geus ³ Anouk den Braber ³³ Giuseppe Delvecchio Chantal Depondt ³⁴ Lieuwe de Haan ³⁵ Greig G de Zubicaray ³⁶ Danai Dima ³⁷ Rali Dimitrova Srdjan Djurovic ³⁸ Hongwei Dong Gary Donohoe ²⁶ Ravindranath Duggirala Thomas Dyer ³⁹ Stefan Ehrlich ⁴⁰ Carl Johan Ekman Torbjørn Elvsåshagen Louise Emsell Susanne Erk ⁴¹ Thomas Espeseth ³⁸ Jesen Fagerness Scott Fears Iryna Fedko Guillén Fernández ²⁰ Simon Fisher ⁴² Tatiana Foroud ⁴³ Peter Fox ³⁹ Clyde Francks ⁴⁴ Sophia D Frangou ⁴⁵ Eva Frey ⁴⁶ Thomas Frodl ⁴⁷ Vincent Frouin ⁴⁸ Hugh Garavan ⁴⁹ Sudheer Giddaluru ⁵⁰ David D Glahn ⁵¹ Beata Godlewska Rita Goldstein ⁵² Randy Gollub ⁵³ Hans J Grabe ⁵⁴ Oliver Grimm ⁵⁵ Oliver Gruber ²⁹ Tulio Guadalupe ⁵⁶ Raquel E Gur Ruben C Gur Harald H H Göring Saskia Hagenaars ²⁹ Tomas Hajek Geoffrey B Hall Jérémy Hall ¹⁶ John Hardy ⁵⁷ Catharina Hartman ³ Johanna Hass ⁵⁸ Sean N Hatton Unn K Haukvik Katrin Hegenscheid ⁵⁹ Andreas Heinz ⁶⁰ Ian Hickie ⁶¹ Beng-Choon Ho ⁶² David Hoehn ⁶³ Pieter Hoekstra ⁶⁴ Marisa Hollinshead Avram J Holmes ⁶⁵ Georg Homuth ⁶⁶ Martine Hoogman ⁶⁷ L Elliot Hong Norbert Hosten ⁵⁹ Jouke-Jan Hottenga ³ Hilleke D Hulshoff Pol ⁶⁸ Kristy S Hwang Clifford R Jack ⁶⁹ Mark Jenkinson ⁷⁰ Caroline Johnston ⁷¹ Erik G Jönsson Rene Kahn ⁷² Dalia Kasperaviciute ⁷³ Sinead M Kelly ⁷⁴ Sungeun Kim ⁷⁵ Peter M Kochunov ⁷⁶ Laura Koenders Bernd Krämer John B J Kwok Jim Lagopoulos Gonzalo Laje ²⁶ Mikael Landén ⁷⁷ Bennett A Landman John Lauriello Stephen M Lawrie Phil Lee ⁷⁸ Stephanie Le Hellard ⁵⁰ Hervé Lemaître ⁷⁹ Cassandra D Leonardo Chiang-Shan Li Benny Liberg David C Liewald Xinmin Liu ⁸⁰ Lorna Lopez ³ Eva Loth ⁸¹ Anbarasu Lourdusamy ⁶ Michelle Luciano ³ Fabio Macciardi ⁸² Marise W J Machielsen Glenda M Macqueen Ulrik F Malt René Mandl ⁶⁸ Dara S Manoach Jean-Luc Martinot ⁸³ Mar Matarin ⁸⁴ Karen Mather ⁸⁵ Manuel Mattheisen ²⁷ Morten Mattingsdal ¹⁰ Andreas Meyer-Lindenberg ⁴¹ Colm Mcdonald ⁸⁶ Andrew Mcintosh ⁸⁷ Francis J. Mcmahon ²⁶ Katie M Mcmahon ⁸⁸ Eva Meisenzahl ⁴⁷ Ingrid Melle ⁸⁹ yuri Milaneschi ⁹⁰ Sebastian Mohnke ⁶⁰ Grant W. Montgomery ³ Derek Morris ²⁶ Eric K Moses Bryon A Mueller Susana Muñoz Maniega ⁹¹ Thomas W. Mühleisen ²⁷ Bertram Müller-Myhsok ⁹² Benson Mwangi ²⁹ Matthias Nauck ⁹³ Kwangsik Nho ⁹⁴ Thomas E Nichols ⁹⁵ Lars-Göran Nilsson Allison C Nugent Lars Nyberg ⁹⁶ Rene L Olvera Jaap Oosterlaan ⁹¹ Roel A. Ophoff ⁹⁷ Massimo Pandolfo ³⁴ Melina Papalampropoulou-Tsiridou Martina Papmeyer ¹⁶ Tomas Paus ⁹⁸ Zdenka Pausova ⁹⁹ Godfrey D Pearlson Brenda Penninx ²⁶ Charles P Peterson Andrea Pfennig ¹⁰⁰ Mary Phillips ¹⁰¹ G. Bruce Pike ⁹⁸ Jean-Baptiste Poline ¹⁰² Steven G Potkin Benno Pütz ¹⁰³ Adaikalavan Ramasamy ¹⁰⁴ Jerod Rasmussen Marcella Rietschel ²⁷ Mark Rijpkema ¹⁰⁵ Shannon L Risacher Joshua L Roffman Roberto Roiz-Santiañez ³¹ Nina Romanczuk-Seiferth ⁶⁰ Emma Rose ¹⁰⁶ Natalie A Royle Dan Rujescu ³ Mina Ryten ¹⁰⁷ Perminder Sachdev ¹⁰⁸ Alireza Salami ¹⁰⁹ Theodore D Satterthwaite ¹¹⁰ Jonathan Savitz Andrew Saykin ⁶⁰ Cathy Scanlon Lianne Schmaal ⁹⁰ Hugo G Schnack Andrew Schork ¹¹¹ S Charles Schulz Remmelt Schür Larry Seidman Li Shen ¹¹² Jody M Shoemaker Andrew Simmons ¹¹³ Sanjay Sisodiya ¹¹⁴ Colin Smith ¹¹⁵ Jordan W. Smoller ¹¹⁶ Jair C Soares Scott R Sponheim Emma Sprooten ⁵¹ John M Starr Vidar Steen ¹¹⁷ Stephen Strakowski Lachlan Strike Jessika Sussmann Philipp G Sämann Alexander Teumer ⁹¹ Arthur W. Toga ¹ Diana Tordesillas-Gutierrez ⁹¹ Daniah Trabzuni ¹¹⁸ Sarah Trost Jessica Turner ¹¹⁹ Martijn D van den Heuvel ²¹ Nic J van Der Wee Kristel van Eijk ⁶⁸ Theo M van Erp ¹²⁰ Neeltje E M van Haren Dennis van ’t Ent ⁹¹ Marie-Jose van Tol ¹²¹ Maria C Valdés Hernández Dick J Veltman ⁹⁰ Amelia Versace ¹⁰¹ Henry Völzke ¹²² Robert Walker ¹²³ Henrik Walter ⁴¹ Lei Wang ¹²⁴ Joanna Wardlaw ¹⁶ Michael E Weale Michael Weiner ¹²⁵ Wei Wen ¹²⁶ Lars Westlye ¹²⁷ Heather C Whalley Christopher D Whelan ² Tonya White ¹²⁸ Anderson M Winkler Katharina Wittfeld ¹²⁹ Girma Woldehawariat ⁸⁰ Christiane Wolf ¹³⁰ David Zilles ¹³¹ Marcel Zwiers ²⁰ Anbupalam Thalamuthu ¹³² Peter R. Schofield ¹³³ Nelson B. Freimer ¹³⁴ Natalia Lawrence ¹³⁵ Wayne Drevets ²⁶

1 LONI - Laboratory of Neuro Imaging [Los Angeles]

2 David Geffen School of Medicine [Los Angeles]

3 Medstar Research Institute

4 Keck School of Medicine [Los Angeles]

5 Génétique Humaine et Fonctions Cognitives

6 Institute of Psychiatry, Psychology & Neuroscience, King's College London

7 Department of Psychiatry

8 Genetic Epidemiology Lab [Brisbane]

9 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]

10 KG Jebsen Centre for Psychosis Research

11 Dalhousie University [Halifax]

12 Molecular and Cellular Therapeutics

13 Department of Genetics

14 UNIVERSIDADE DO PORTO - Departamento de Matemática Pura, Faculdade de Ciências

15 Department of Psychiatry and Psychotherapy

16 University of Edinburgh

17 Center for Sepsis Control & Care

18 Division Genetic Epidemiology in Psychiatry

19 Texas Biomedical Research Institute [San Antonio, TX]

20 Donders Institute for Brain, Cognition and Behaviour

21 Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht 3584 CX, The Netherlands

22 Radboud University Medical Center [Nijmegen]

23 Department of Psychiatry [Boston]

24 Karakter Child and Adolescent Psychiatry University Centre [Nijmegen]

25 N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia

26 Human Genetics Branch

27 Department of Genomics

28 Douglas Mental Health University Institute

29 sans affiliation

30 Università degli Studi di Salermo

31 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]

32 Bijvoet Center of Biomolecular Research [Utrecht]

33 Biological Psychology, Neuroscience Campus Amsterdam & EMGO Institute for Health and Care Research, VU University & VU Medical Center, Amsterdam 1081 BT, The Netherlands

34 Department of Neurology

35 Department of Psychiatry [Pittsburgh]

36 School of Psychology, University of Queensland

37 Department of Hematology

38 UiO - University of Oslo

39 UTHealth - The University of Texas Health Science Center at Houston

40 MetaGenoPolis

41 Department of Psychiatry, Division of Medical Psychology

42 Champalimaud Neuroscience Programme

43 Department of Medical and Molecular Genetics

44 Language and Genetics Department [Nijmegen]

45 MSSM - Icahn School of Medicine at Mount Sinai [New York]

46 Division of Hemato-Oncology

47 Psychiatry and Psychotherapy

48 NEUROSPIN - Service NEUROSPIN

49 University of Vermont [Burlington]

50 Haukeland University Hospital

51 Dpt of Psychiatry [New Haven]

52 Laboratory of Molecular Neuropsychiatry

53 Athinoula A. Martinos Center for Biomedical Imaging

54 Department of Psychiatry and Psychotherapy

55 Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim

56 IMPRS - International Max Planck Research School for Language Sciences

57 Lancaster University

58 Georgia Institute of Technology [Atlanta]

59 Greifswald University Hospital

60 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]

61 Clinical Research Unit

62 Department of Psychiatry, University of Iowa

63 Max Planck Institute of Psychiatry

64 UMCG - University Medical Center Groningen [Groningen]

65 Massachusetts General Hospital [Boston]

66 Interfaculty Institute for Genetics and Functional Genomics

67 Mental Health Sciences Unit

68 University Medical Center [Utrecht]

69 Department of Radiology [Rochester]

70 Department of Clinical Neurology [Oxford]

71 Centre for the Cellular Basis of Behavior

72 BETA - Bureau d'Économie Théorique et Appliquée

73 Department of Medicine

74 MetaCase [Jyväskylä]

75 SRSMC - Structure et Réactivité des Systèmes Moléculaires Complexes

76 Department of Psychiatry

77 Sahlgrenska Academy at University of Gothenburg [Göteborg]

78 BROAD INSTITUTE - Broad Institute of MIT and Harvard

79 UCP - Université de Cergy Pontoise

80 NIH - National Institutes of Health [Bethesda]

81 Department of Forensic and Neurodevelopmental Sciences

King‘s College London

82 UCI - University of California [Irvine]

83 U1000 - Neuroimagerie en psychiatrie

84 Clinical And Experimental Epilepsy

85 Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia

86 Department of Life Sciences

87 MSI - Mathematical Sciences Institute

88 Centre for Advanced Imaging

89 Division of Mental Health and Addiction

90 Department of Psychiatry

91 Metacohorts Consortium

92 Translational Centre for Regenerative Medicine (TRM); Department of Cell Therapy

93 Institute of Clinical Chemistry and Laboratory Medicine

94 Indiana Alzheimer Disease Center

95 Department of Statistics [Warwick]

96 Department of Health Science, Division of Health and Rehabilitation

97 Department of Psychiatry

98 MNI - McConnell Brain Imaging Centre

99 Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada

100 Department of Psychiatry and Psychotherapy

101 Department of Psychiatry

102 PARIETAL - Modelling brain structure, function and variability based on high-field MRI data

NEUROSPIN - Service NEUROSPIN, Inria Saclay - Ile de France

103 Statistical Genetics Group

104 Respiratory Epidemiology and Public Health

105 Donders Center for Cognitive Neuroimaging

106 IPCM - Institut Parisien de Chimie Moléculaire

107 Department of Medical and Molecular Genetics

108 Centre for Healthy Brain Ageing

109 Umeå Centre for Functional Brain Imaging (UFBI), Umeå University, Umeå 901 87, Sweden

110 University of Pennsylvania [Philadelphia]

111 Department of Cognitive Sciences [San Diego]

112 Indiana University School of Medicine

113 Natbrainlab, Department of Forensic and Neurodevelopmental Sciences

114 Institute of Neurology [London]

115 UMR LSTM - Laboratoire des symbioses tropicales et méditerranéennes

116 Stanley Center for Psychiatric Research

117 UiB - University of Bergen

118 Department of Genetics

119 Georgia State University

120 Department of Psychiatry and Human Behavior [Irvine]

121 Leiden University Medical Center (LUMC)

122 Institute for Community Medicine

123 UNSW - School of Music and Music Education

124 Science & Technology Information Institute

125 UCSF - University of California [San Francisco]

126 Department of Physics [Hong Kong University of Science and Technology]

127 Department of Psychology [Oslo]

128 Research Laboratory for Archaeology & the History of Art

129 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen

130 Dundee Technopole

131 Department of Psychiatry and Psychotherapy

132 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia

133 Prince of Wales Medical Research Institute

134 Center for Neurobehavioral Genetics

135 Wales Institute of Cognitive Neuroscience

Abstract : The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Life Sciences [q-bio] / Neurons and Cognition [q-bio.NC]

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Submitted on : Sunday, December 30, 2018 - 6:06:50 PM
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