The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Paul Thompson 1 Jason Stein 2 Sarah Medland 3 Derrek Hibar 4 Alejandro Vasquez Miguel Renteria Roberto Toro 5 Neda Jahanshad 2 Gunter Schumann 6 Barbara Franke 7 Margaret Wright 8 Nicholas Martin 9 Ingrid Agartz 10 Martin Alda 11 Saud Alhusaini 12 Laura Almasy 13 Jorge Almeida 14 Kathryn Alpert Nancy Andreasen Ole Andreassen 10 Liana Apostolova Katja Appel 15 Nicola Armstrong Benjamin Aribisala Mark Bastin 16 Michael Bauer 17 Carrie Bearden 7 Ørjan Bergmann Elisabeth Binder 18 John Blangero 19 Henry Bockholt Erlend Bøen Catherine Bois Dorret Boomsma 3 Tom Booth Ian Bowman Janita Bralten 20 Rachel Brouwer 21 Han Brunner 22 David Brohawn Randy Buckner 23 Jan Buitelaar 24 Kazima Bulayeva 25 Juan Bustillo Vince Calhoun Dara Cannon 26 Rita Cantor 27 Melanie Carless Xavier Caseras Gianpiero Cavalleri M. Mallar Chakravarty 28 Kiki Chang Christopher Ching 29 Andrea Christoforou Sven Cichon 27 Vincent Clark Patricia Conrod 6 Giovanni Coppola 30 Benedicto Crespo-Facorro 31 Joanne Curran Michael Czisch 32 Ian Deary 3 Eco de Geus 3 Anouk Den Braber 33 Giuseppe Delvecchio Chantal Depondt 34 Lieuwe de Haan 35 Greig de Zubicaray 36 Danai Dima 37 Rali Dimitrova Srdjan Djurovic 38 Hongwei Dong Gary Donohoe 26 Ravindranath Duggirala Thomas Dyer 39 Stefan Ehrlich 40 Carl Ekman Torbjørn Elvsåshagen Louise Emsell Susanne Erk 41 Thomas Espeseth 38 Jesen Fagerness Scott Fears Iryna Fedko Guillén Fernández 20 Simon Fisher 42 Tatiana Foroud 43 Peter Fox 39 Clyde Francks 44 Sophia Frangou 45 Eva Frey 46 Thomas Frodl 47 Vincent Frouin 48 Hugh Garavan 49 Sudheer Giddaluru 50 David Glahn 51 Beata Godlewska Rita Goldstein 52 Randy Gollub 53 Hans Grabe 54 Oliver Grimm 55 Oliver Gruber 29 Tulio Guadalupe 56 Raquel Gur Ruben Gur Harald Göring Saskia Hagenaars 29 Tomas Hajek Geoffrey Hall Jérémy Hall 16 John Hardy 57 Catharina Hartman 3 Johanna Hass 58 Sean Hatton Unn Haukvik Katrin Hegenscheid 59 Andreas Heinz 60 Ian Hickie 61 Beng-Choon Ho 62 David Hoehn 63 Pieter Hoekstra 64 Marisa Hollinshead Avram Holmes 65 Georg Homuth 66 Martine Hoogman 67 L Hong Norbert Hosten 59 Jouke-Jan Hottenga 3 Hilleke Hulshoff Pol 68 Kristy Hwang Clifford Jack 69 Mark Jenkinson 70 Caroline Johnston 71 Erik Jönsson Rene Kahn 72 Dalia Kasperaviciute 73 Sinead Kelly 74 Sungeun Kim 75 Peter Kochunov 76 Laura Koenders Bernd Krämer John Kwok Jim Lagopoulos Gonzalo Laje 26 Mikael Landén 77 Bennett Landman John Lauriello Stephen Lawrie Phil Lee 78 Stephanie Le Hellard 50 Hervé Lemaître 79 Cassandra Leonardo Chiang-Shan Li Benny Liberg David Liewald Xinmin Liu 80 Lorna Lopez 3 Eva Loth 81 Anbarasu Lourdusamy 6 Michelle Luciano 3 Fabio Macciardi 82 Marise Machielsen Glenda Macqueen Ulrik Malt René Mandl 68 Dara Manoach Jean-Luc Martinot 83 Mar Matarin 84 Karen Mather 85 Manuel Mattheisen 27 Morten Mattingsdal 10 Andreas Meyer-Lindenberg 41 Colm Mcdonald 86 Andrew Mcintosh 87 Francis Mcmahon 26 Katie Mcmahon 88 Eva Meisenzahl 47 Ingrid Melle 89 Yuri Milaneschi 90 Sebastian Mohnke 60 Grant Montgomery 3 Derek Morris 26 Eric Moses Bryon Mueller Susana Muñoz Maniega 91 Thomas Mühleisen 27 Bertram Müller-Myhsok 92 Benson Mwangi 29 Matthias Nauck 93 Kwangsik Nho 94 Thomas Nichols 95 Lars-Göran Nilsson Allison Nugent Lars Nyberg 96 Rene Olvera Jaap Oosterlaan 91 Roel Ophoff 97 Massimo Pandolfo 34 Melina Papalampropoulou-Tsiridou Martina Papmeyer 16 Tomas Paus 98 Zdenka Pausova 99 Godfrey Pearlson Brenda Penninx 26 Charles Peterson Andrea Pfennig 100 Mary Phillips 101 G. Bruce Pike 98 Jean-Baptiste Poline 102 Steven Potkin Benno Pütz 103 Adaikalavan Ramasamy 104 Jerod Rasmussen Marcella Rietschel 27 Mark Rijpkema 105 Shannon Risacher Joshua Roffman Roberto Roiz-Santiañez 31 Nina Romanczuk-Seiferth 60 Emma Rose 106 Natalie Royle Dan Rujescu 3 Mina Ryten 107 Perminder Sachdev 108 Alireza Salami 109 Theodore Satterthwaite 110 Jonathan Savitz Andrew Saykin 60 Cathy Scanlon Lianne Schmaal 90 Hugo Schnack Andrew Schork 111 S Schulz Remmelt Schür Larry Seidman Li Shen 112 Jody Shoemaker Andrew Simmons 113 Sanjay Sisodiya 114 Colin Smith 115 Jordan Smoller 116 Jair Soares Scott Sponheim Emma Sprooten 51 John Starr Vidar Steen 117 Stephen Strakowski Lachlan Strike Jessika Sussmann Philipp Sämann Alexander Teumer 91 Arthur Toga 1 Diana Tordesillas-Gutierrez 91 Daniah Trabzuni 118 Sarah Trost Jessica Turner 119 Martijn Van den Heuvel 21 Nic Van Der Wee Kristel Van Eijk 68 Theo Van Erp 120 Neeltje Van Haren Dennis Van ’t Ent 91 Marie-Jose Van Tol 121 Maria Valdés Hernández Dick Veltman 90 Amelia Versace 101 Henry Völzke 122 Robert Walker 123 Henrik Walter 41 Lei Wang 124 Joanna Wardlaw 16 Michael Weale Michael Weiner 125 Wei Wen 126 Lars Westlye 127 Heather Whalley Christopher Whelan 2 Tonya White 128 Anderson Winkler Katharina Wittfeld 129 Girma Woldehawariat 80 Christiane Wolf 130 David Zilles 131 Marcel Zwiers 20 Anbupalam Thalamuthu 132 Peter Schofield 133 Nelson Freimer 134 Natalia Lawrence 135 Wayne Drevets 26
102 PARIETAL - Modelling brain structure, function and variability based on high-field MRI data
NEUROSPIN - Service NEUROSPIN, Inria Saclay - Ile de France
121 LUMC
Abstract : The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
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Paul Thompson, Jason Stein, Sarah Medland, Derrek Hibar, Alejandro Vasquez, et al.. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain imaging and behavior (Brain Imaging Behav), Secaucus, NJ : Springer, 2014, 8 (2), pp.152-182. ⟨10.1007/s11682-013-9269-5⟩. ⟨pasteur-01967166⟩

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