Skip to Main content Skip to Navigation
Journal articles

KCTD8 Gene and Brain Growth in Adverse Intrauterine Environment: A Genome-wide Association Study

Abstract : The most dramatic growth of the human brain occurs in utero and during the first 2 years of postnatal life. Genesis of the cerebral cortex involves cell proliferation, migration, and apoptosis, all of which may be influenced by prenatal environment. Here, we show that variation in KCTD8 (potassium channel tetramerization domain 8) is associated with brain size in female adolescents (rs716890, P 5 5.40 3 10 209). Furthermore, we found that the KCTD8 locus interacts with prenatal exposure to maternal cigarette smoking visa `-vis cortical area and cortical folding: In exposed girls only, the KCTD8 locus explains up to 21% of variance. Using head circumference as a proxy of brain size at 7 years of age, we have replicated this gene-environment interaction in an independent sample. We speculate that KCTD8 might modulate adverse effects of smoking during pregnancy on brain development via apoptosis triggered by low intracellular levels of potassium, possibly reducing the number of progenitor cells.
Complete list of metadatas

Cited literature [49 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01967146
Contributor : Roberto Toro <>
Submitted on : Sunday, December 30, 2018 - 5:37:54 PM
Last modification on : Thursday, June 18, 2020 - 12:32:06 PM

Links full text

Identifiers

Collections

Citation

Tomáš Paus, Manon Bernard, M. Mallar Chakravarty, George Davey Smith, Jesse Gillis, et al.. KCTD8 Gene and Brain Growth in Adverse Intrauterine Environment: A Genome-wide Association Study. Cerebral Cortex, Oxford University Press (OUP), 2012, 22 (11), pp.2634-2642. ⟨10.1093/cercor/bhr350⟩. ⟨pasteur-01967146⟩

Share

Metrics

Record views

141