Skip to Main content Skip to Navigation
Journal articles

Standardized Immunomonitoring: Separating the Signals from the Noise

Darragh Duffy 1, *
Abstract : Classical immunoassays are routinely performed in the clinic for disease diagnosis and monitoring. Recent advances in phenotyping technologies offer huge potential in expanding the breadth of immune response monitoring. Challenges remain, however, in translating many of these tools to routine clinical practice. This Opinion focuses on two strategies that may advance the clinical adoption of immune-based biomarkers: protein-based assays employing digital readouts can reduce nonspecific signals that limit more classical assays; and approaches that stimulate immune responses in more standardized ways can help to reveal disease-specific immune response signatures by elevating the signal above the background. The integration of such immune response phenotypes is a critical step for the increased implementation of precision medicine-based strategies.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-01962529
Contributor : Marie-Christine Vougny <>
Submitted on : Thursday, December 20, 2018 - 4:23:51 PM
Last modification on : Monday, January 13, 2020 - 5:08:18 PM

Links full text

Identifiers

Collections

Citation

Darragh Duffy. Standardized Immunomonitoring: Separating the Signals from the Noise. Trends in Biotechnology, Elsevier, 2018, 36 (11), pp.1107-1115. ⟨10.1016/j.tibtech.2018.06.002⟩. ⟨pasteur-01962529⟩

Share

Metrics

Record views

83