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Journal articles
Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity
Simone Joas
1
Erica Parrish
2
Clement Gnanadurai
1
Edina Lump
1
Christina Stürzel
1
Nicholas Parrish
2
Gerald Learn
2
Ulrike Sauermann
3
Berit Neumann
3
Kerstin Mätz Rensing
3
Dietmar Fuchs
4
James Billingsley
5
Steven Bosinger
5
Guido Silvestri
5
Cristian Apetrei
6
Nicolas Huot
7, 8
Thalía Garcia-Tellez
7
Michaela Muller-Trutwin
7
Dominik Hotter
1
Daniel Sauter
1
Christiane Stahl-Hennig
3
Beatrice Hahn
2
Frank Kirchhoff
1
Christina M Stürzel 1
Author
Nicholas F Parrish 2
Author
Gerald H Learn 2
Author
Ulrike Sauermann 3
Author
Berit Neumann 3
Author
Kerstin Mätz Rensing 3
Author
Dietmar Fuchs 4
Author
James M Billingsley 5
Author
Steven E Bosinger 5
Author
Guido Silvestri 5
Author
Cristian Apetrei 6
Author
Nicolas Huot 7, 8
Author IdHAL : nicolas-huot ORCID : https://orcid.org/0000-0001-5982-7991
Thalía Garcia-Tellez 7
Author
Michaela Muller-Trutwin 7
Author IdHAL : michaela-muller-trutwin ORCID : https://orcid.org/0000-0002-3854-2396
Dominik Hotter 1
Author
Daniel Sauter 1
Author
1
Universität Ulm - Ulm University [Ulm, Allemagne] (Helmholtzstraße 16, 89081 Ulm - Germany)
2
University of Pennsylvania [Philadelphia] (3451 Walnut Street, Philadelphia, PA 19104 | 215-898-5000 - United States)
3
German Primate Centre (France)
4
IMU - Innsbruck Medical University [Austria] (Innrain 52, Christoph-Probst-Platz, 6020 Innsbruck - Austria)
5
Emory University [Atlanta, GA] (201 Dowman Dr, Atlanta, GA 30322 - United States)
6
PITT - University of Pittsburgh (4200 Fifth Avenue Pittsburgh, PA 15260 - United States)
- Pennsylvania Commonwealth System of Higher Education (PCSHE) (United States)
7
HIV, Inflammation et persistance (Département Virologie, 25-28 rue du Docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
8
VRI - Vaccine Research Institute (61 avenue du Général de Gaulle 94010 Créteil Cedex France - France)
- UPEC UP12 - Université Paris-Est Créteil Val-de-Marne - Paris 12 (61 avenue du Général de Gaulle - 94010 Créteil cedex - France)
Abstract : HIV-1 causes chronic inflammation and AIDS in humans, whereas related simian immunodeficiency viruses (SIVs) replicate efficiently in their natural hosts without causing disease. It is currently unknown to what extent virus-specific properties are responsible for these different clinical outcomes. Here, we incorporate two putative HIV-1 virulence determinants, i.e., a Vpu protein that antagonizes tetherin and blocks NF-κB activation and a Nef protein that fails to suppress T cell activation via downmodulation of CD3, into a non-pathogenic SIVagm strain and test their impact on viral replication and pathogenicity in African green monkeys. Despite sustained high-level viremia over more than 4 years, moderately increased immune activation and transcriptional signatures of inflammation, the HIV-1-like SIVagm does not cause immunodeficiency or any other disease. These data indicate that species-specific host factors rather than intrinsic viral virulence factors determine the pathogenicity of primate lentiviruses.
Document type :
Journal articles
Complete list of metadata
https://hal-pasteur.archives-ouvertes.fr/pasteur-01959320
Contributor : Brigitte Bidault Connect in order to contact the contributor
Submitted on : Tuesday, December 18, 2018 - 4:19:08 PM
Last modification on : Wednesday, November 3, 2021 - 6:48:24 AM
Long-term archiving on: : Wednesday, March 20, 2019 - 11:35:48 AM
Contributor : Brigitte Bidault Connect in order to contact the contributor
Submitted on : Tuesday, December 18, 2018 - 4:19:08 PM
Last modification on : Wednesday, November 3, 2021 - 6:48:24 AM
Long-term archiving on: : Wednesday, March 20, 2019 - 11:35:48 AM
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species-specific-host-factors-...
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License
Identifiers
- HAL Id : pasteur-01959320, version 1
- DOI : 10.1038/s41467-018-03762-3
- PUBMED : 29636452
- PUBMEDCENTRAL : PMC5893559
Citation
Simone Joas, Erica Parrish, Clement Gnanadurai, Edina Lump, Christina Stürzel, et al.. Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity. Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.1371 - 1371. ⟨10.1038/s41467-018-03762-3⟩. ⟨pasteur-01959320⟩
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