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Journal Articles Nature Communications Year : 2018

Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

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Ulrike Sauermann
  • Function : Author
  • PersonId : 912071
Christiane Stahl-Hennig
  • Function : Author
  • PersonId : 912073
Beatrice Hahn
  • Function : Author
  • PersonId : 919207

Abstract

HIV-1 causes chronic inflammation and AIDS in humans, whereas related simian immunodeficiency viruses (SIVs) replicate efficiently in their natural hosts without causing disease. It is currently unknown to what extent virus-specific properties are responsible for these different clinical outcomes. Here, we incorporate two putative HIV-1 virulence determinants, i.e., a Vpu protein that antagonizes tetherin and blocks NF-κB activation and a Nef protein that fails to suppress T cell activation via downmodulation of CD3, into a non-pathogenic SIVagm strain and test their impact on viral replication and pathogenicity in African green monkeys. Despite sustained high-level viremia over more than 4 years, moderately increased immune activation and transcriptional signatures of inflammation, the HIV-1-like SIVagm does not cause immunodeficiency or any other disease. These data indicate that species-specific host factors rather than intrinsic viral virulence factors determine the pathogenicity of primate lentiviruses.
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pasteur-01959320 , version 1 (18-12-2018)

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Attribution - CC BY 4.0

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Simone Joas, Erica H Parrish, Clement W Gnanadurai, Edina Lump, Christina M Stürzel, et al.. Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity. Nature Communications, 2018, 9 (1), pp.1371 - 1371. ⟨10.1038/s41467-018-03762-3⟩. ⟨pasteur-01959320⟩

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