A. A. Aravin, M. Lagos-quintana, A. Yalcin, M. Zavolan, D. Marks et al., The small RNA profile during Drosophila melanogaster development, Dev. Cell, vol.5, pp.337-350, 2003.

D. P. Bartel, MicroRNAs: Genomics, biogenesis, mechanism, and function, Cell, vol.116, pp.281-297, 2004.

D. Baulcombe, RNA silencing in plants, Nature, vol.431, pp.356-363, 2004.

N. Baumberger and D. C. Baulcombe, Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs, Proc. Natl. Acad. Sci, vol.102, pp.11928-11933, 2005.

I. Bentwich, A. Avniel, Y. Karov, R. Aharonov, S. Gilad et al., Identification of hundreds of conserved and nonconserved human microRNAs, Nat. Genet, vol.37, pp.766-770, 2005.

E. Berezikov, V. Guryev, J. Van-de-belt, E. Wienholds, R. H. Plasterk et al., Phylogenetic shadowing and computational identification of human microRNA genes, Cell, vol.120, pp.21-24, 2005.

C. A. Brennan and K. V. Anderson, Drosophila: The genetics of innate immune recognition and response, Annu. Rev. Immunol, vol.22, pp.457-483, 2004.

K. Y. Chang and A. Ramos, The double-stranded RNAbinding motif, a versatile macromolecular docking platform, FEBS J, vol.272, pp.2109-2117, 2005.

J. A. Chao, J. H. Lee, B. R. Chapados, E. W. Debler, A. Schneemann et al., Dual modes of RNA-silencing suppression by Flock House virus protein B2, Nat. Struct. Mol. Biol, vol.12, pp.952-957, 2005.

S. Cherry and N. Perrimon, Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis, Nat. Immunol, vol.5, pp.81-87, 2004.

A. Deleris, J. Gallego-bartolome, J. Bao, K. D. Kasschau, J. C. Carrington et al., Hierarchical action and inhibition of plant Dicer-like proteins in antiviral defense, Science, vol.313, pp.68-71, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00092877

D. Galiana-arnoux, C. Dostert, A. Schneemann, J. A. Hoffmann, and J. L. Imler, Essential function in vivo for Dicer-2 in host defense against RNA viruses in Drosophila, Nat. Immunol, vol.7, pp.590-597, 2006.

L. Gitlin and R. Andino, Nucleic acid-based immune system: The antiviral potential of mammalian RNA silencing, J. Virol, vol.77, pp.7159-7165, 2003.

L. Gitlin, S. Karelsky, A. , and R. , Short interfering RNA confers intracellular antiviral immunity in human cells, Nature, vol.418, pp.430-434, 2002.

L. Gitlin, J. K. Stone, A. , and R. , Poliovirus escape from RNAi: siRNA-target recognition and implications for therapeutic approaches, J. Virol, vol.79, pp.1027-1035, 2005.

B. Haley, G. Tang, and P. D. Zamore, In vitro analysis of RNA interference in Drosophila melanogaster, Methods, vol.30, pp.330-336, 2003.

B. John, A. J. Enright, A. Aravin, T. Tuschl, C. Sander et al., Human MicroRNA targets, PLoS Biol, vol.2, p.363, 2004.

K. M. Keene, B. D. Foy, I. Sanchez-vargas, B. J. Beaty, C. D. Blair et al., RNA interference acts as a natural antiviral response to O'nyong-nyong virus, 2004.

, Togaviridae) infection of Anopheles gambiae, Proc. Natl. Acad. Sci, vol.101, pp.17240-17245

L. Lakatos, T. Csorba, V. Pantaleo, E. J. Chapman, J. C. Carrington et al., Small RNA binding is a common strategy to suppress RNA silencing by several viral suppressors, EMBO J, vol.25, pp.2768-2780, 2006.

Y. S. Lee, K. Nakahara, J. W. Pham, K. Kim, Z. He et al., Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways, Cell, vol.117, pp.69-81, 2004.

H. W. Li, W. X. Li, and S. W. Ding, Induction and suppression of RNA silencing by an animal virus, Science, vol.296, pp.1319-1321, 2002.

A. Lingel, B. Simon, E. Izaurralde, and M. Sattler, The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of doublestranded RNA recognition, EMBO Rep, vol.6, pp.1149-1155, 2005.

J. Liu, M. A. Carmell, F. V. Rivas, C. G. Marsden, J. M. Thomson et al., Argonaute2 is the catalytic engine of mammalian RNAi, Science, vol.305, pp.1437-1441, 2004.

R. Lu, M. Maduro, F. Li, H. W. Li, G. Broitman-maduro et al., Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans, Nature, vol.436, pp.1040-1043, 2005.

G. Meister and T. Tuschl, Mechanisms of gene silencing by double-stranded RNA, Nature, vol.431, pp.343-349, 2004.

Z. Merai, Z. Kerenyi, S. Kertesz, M. Magna, L. Lakatos et al., Double-stranded RNA binding may be a general plant RNA viral strategy to suppress RNA silencing, J. Virol, vol.80, pp.5747-5756, 2006.

K. Okamura, A. Ishizuka, H. Siomi, and M. C. Siomi, Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways, Genes & Dev, vol.18, pp.1655-1666, 2004.

L. J. Reed and H. Muench, A simple method of estimating fifty percent endpoints, Am J. Hyg, vol.27, pp.493-497, 1938.

P. Rorth, Gal4 in the Drosophila female germline, Mech. Dev, vol.78, pp.113-118, 1998.

. Van-rij,

J. M. Ryter and S. C. Schultz, Molecular basis of doublestranded RNA-protein interactions: Structure of a dsRNAbinding domain complexed with dsRNA, EMBO J, vol.17, pp.7505-7513, 1998.

M. C. Saleh, R. P. Van-rij, A. Hekele, A. Gillis, E. Foley et al., The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing, Nat. Cell Biol, vol.8, pp.793-802, 2006.

I. Sanchez-vargas, E. A. Travanty, K. M. Keene, A. W. Franz, B. J. Beaty et al., RNA interference, arthropod-borne viruses, and mosquitoes, Virus Res, vol.102, pp.65-74, 2004.

A. M. Silverstein, The history of immunology, Fundamental immunology, pp.21-38, 1989.

C. Sullivan and D. Ganem, A virus-encoded inhibitor that blocks RNA interference in mammalian cells, J. Virol, vol.79, pp.7371-7379, 2005.

B. Tian, P. C. Bevilacqua, A. Diegelman-parente, and M. B. Mathews, The double-stranded-RNA-binding motif: Interference and much more, Nat. Rev. Mol. Cell Biol, vol.5, pp.1013-1023, 2004.

R. P. Van-rij and R. Andino, The silent treatment: RNAi as a defense against virus infection in mammals, Trends Biotechnol, vol.24, pp.186-193, 2006.

J. M. Vargason, G. Szittya, J. Burgyan, T. Hall, and T. M. , Size selective recognition of siRNA by an RNA silencing suppressor, Cell, vol.115, pp.799-811, 2003.

O. Voinnet, Induction and suppression of RNA silencing: Insights from viral infections, Nat. Rev. Genet, vol.6, pp.206-220, 2005.

X. H. Wang, R. Aliyari, W. X. Li, H. W. Li, K. Kim et al., RNA interference directs innate immunity against viruses in adult Drosophila, Science, vol.312, pp.452-454, 2006.
DOI : 10.1126/science.1125694

URL : http://science.sciencemag.org/content/312/5772/452.full.pdf

Z. Xie, L. K. Johansen, A. M. Gustafson, K. D. Kasschau, A. D. Lellis et al., Genetic and functional diversification of small RNA pathways in plants, PLoS Biol, vol.2, p.104, 2004.

K. Ye, L. Malinina, P. , and D. J. , Recognition of small interfering RNA by a viral suppressor of RNA silencing, Nature, vol.426, pp.874-878, 2003.