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Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice

Abstract : The physiologic role played by plasmacytoid dendritic cells (pDCs) in the induction of innate responses and inflammation in response to pathogen signaling is not well understood. Here, we describe a new mouse model lacking pDCs and establish that pDCs are essential for the in vivo induction of NK-cell activity in response to Toll-like receptor 9 (TLR9) triggering. Furthermore, we provide the first evidence that pDCs are critical for the systemic production of a wide variety of chemokines in response to TLR9 activation. Consequently, we observed a profound alteration in monocyte, macrophage, neutrophil, and NK-cell recruitment at the site of inflammation in the absence of pDCs in response to CpG-Dotap and stimulation by microbial pathogens, such as Leishmania major, Escherichia coli, and Mycobacterium bovis. This study, which is based on the development of a constitutively pDC-deficient mouse model, highlights the pivotal role played by pDCs in the induction of innate immune responses and inflammation after TLR9 triggering.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01942449
Contributor : Gilles Dadaglio <>
Submitted on : Monday, December 3, 2018 - 11:25:06 AM
Last modification on : Monday, January 13, 2020 - 5:08:15 PM

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Camille Guillerey, Juliette Mouriès, Giulia Polo, Noëlle Doyen, Helen Law, et al.. Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice. Blood, American Society of Hematology, 2012, 120 (1), pp.90-99. ⟨10.1182/blood-2012-02-410936⟩. ⟨pasteur-01942449⟩

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