Development of a simple score based on HBeAg and ALT for selecting patients for HBV treatment in Africa

Yusuke Shimakawa (1) , Ramou Njie (2) , Gibril Ndow (3) , Muriel Vray (1, 4) , Papa Saliou Mbaye (5) , Philippe Bonnard (6) , Roger Sombié (7) , Jean Nana (8) , Vincent Leroy (8) , Julie Bottero (9) , Patrick Ingiliz (10) , Gerrit Post (10, 11) , Bakary Sanneh (12) , Ignatius Baldeh (12) , Penda Suso (2) , Amie Ceesay , Adam Jeng , Harr Freeya Njai , Shevanthi Nayagam (3) , Umberto d'Alessandro , Isabelle Chemin (13) , Maimuna Mendy (14) , Mark Thursz (3) , Maud Lemoine (3)

1 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
2 MRC - Medical Research Council Unit The Gambia
3 Imperial College London
4 Unité d'Epidémiologie des Maladies Infectieuses
5 Hôpital Principal de Dakar
6 CHU Tenon [AP-HP]
7 Service d’Hépato-gastroentérologie [Ouagadougou, Burkina-Faso]
8 UGA UFRM - Université Grenoble Alpes - UFR Médecine
9 CHU Saint-Antoine [AP-HP]
10 ZIBP - Center for Infectiology = Zentrum für Infektiologie [Berlin, Germany]
11 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
12 National Public Health Laboratory [Banjul, The Gambia]
13 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
14 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer

To eliminate hepatitis B virus (HBV) infection, it is essential to scale up antiviral treatment through decentralized services. However, access to the conventional tools to assess treatment eligibility (liver biopsy/Fibroscan®/HBV DNA) is limited and not affordable in resource-limited countries. We developed and validated a simple score to easily identify patients in need of HBV treatment in Africa.

Keywords: Africa; Diagnostic score; Elimination; Hepatitis B; Patient care management; Sensitivity and specificity; Validation studies

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Life Sciences [q-bio]; Human health and pathology; Hépatology and Gastroenterology

Yusuke Shimakawa, Ramou Njie, Gibril Ndow, Muriel Vray, Papa Saliou Mbaye, et al.. Development of a simple score based on HBeAg and ALT for selecting patients for HBV treatment in Africa. Journal of Hepatology, 2018, 69 (4), pp.776 - 784. ⟨10.1016/j.jhep.2018.05.024⟩. ⟨pasteur-01896895⟩