Ubiquitin, SUMO, and NEDD8: Key Targets of Bacterial Pathogens

David Ribet (1, 2, 3) , Pascale Cossart (4)

1 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
2 IRIB - Institute for Research and Innovation in Biomedicine
3 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
4 UIBC - Interactions Bactéries-Cellules

Manipulation of host protein post-translational modifications (PTMs) is used by various pathogens to interfere with host cell functions. Among these modifications, ubiquitin (UBI) and ubiquitin-like proteins (UBLs) constitute key targets because they are regulators of pathways essential for the host cell. In particular, these PTM modifiers control pathways that have been described as crucial for infection such as pathogen entry, replication, propagation, or detection by the host. Although bacterial pathogens lack eucaryotic-like UBI or UBL systems, many of them produce proteins that specifically interfere with these host PTMs during infection. In this review we discuss the different mechanisms used by bacteria to interfere with host UBI and the two UBLs, SUMO and NEDD8.

Keywords: NEDD8; SUMO; ISG15; ubiquitin; host–pathogen interactions

Domains: Cellular Biology

David Ribet, Pascale Cossart. Ubiquitin, SUMO, and NEDD8: Key Targets of Bacterial Pathogens. Trends in Cell Biology, 2018, 28 (11), pp.926-940. ⟨10.1016/j.tcb.2018.07.005⟩. ⟨pasteur-01890548v2⟩