Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC + CD4 + cell levels: a surrogate marker candidate of HIV-induced intestinal damage

Mickaël Ploquin (1) , Armanda Casrouge (2) , Yoann Madec (3) , Nicolas Noël (1, 4) , Béatrice Jacquelin (1) , Nicolas Huot (1) , Darragh Duffy (2) , Simon P Jochems (1) , Luca Micci (5) , Camille Lecuroux (4) , Faroudy Boufassa (6) , Thijs Booiman , Thalía Garcia-Tellez (1) , Mathilde Ghislain (6) , Roger Le Grand (4) , Olivier Lambotte (4) , Neeltje Kootstra , Laurence Meyer (6) , Cécile Goujard (6) , Mirko Paiardini (5) , Matthew Albert (2) , Michaela Müller-Trutwin (1)

1 HIV, Inflammation et persistance - HIV, Inflammation and Persistence
2 Immunobiologie des Cellules dendritiques
3 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
4 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
5 Yerkes National Primate Research Center [Lawrenceville, GA]
6 CESP - Centre de recherche en épidémiologie et santé des populations

Combined anti-retroviral therapy (cART) transformed HIV-1 from a deadly disease into a chronic infection, but does not cure HIV infection. It also does not fully restore HIV-induced gut damage unless administered extremely early after infection. Additional biomarkers are needed to evaluate the capacity of therapies aimed at HIV remission/cure to restore HIV-induced intestinal immune damage and limit chronic inflammation. Herein, we aimed to identify a systemic surrogate marker whose levels would reflect gut immune damage such as intestinal Th17 cell loss starting from primary HIV-1 infection.

Keywords: biomarker; Th17; SIV; dipeptidylpeptidase; inflammation; intestine; HIV

Domains: Life Sciences [q-bio]; Immunology

Mickaël Ploquin, Armanda Casrouge, Yoann Madec, Nicolas Noël, Béatrice Jacquelin, et al.. Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC + CD4 + cell levels: a surrogate marker candidate of HIV-induced intestinal damage. Journal of the International AIDS Society, 2018, 21 (7), pp.e25144. ⟨10.1002/jia2.25144⟩. ⟨pasteur-01880368⟩